Pdgfa - platelet derived growth factor, alpha Gene

Also Known as PDGF-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18590

Summary

Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in digestive tract development and embryonic lung development. Acts upstream of or within several processes, including animal organ development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Located in extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfa Products (2)

mRNA Protein Name
NM_001363271.1 NP_001350200.1 platelet-derived growth factor subunit A isoform 2 precursor
NM_008808.4 NP_032834.1 platelet-derived growth factor subunit A isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
12176888 MGI
acts upstream of or within angiogenesis IDA
IDA: Inferred from direct assay
12101409 MGI
acts upstream of or within animal organ morphogenesis IGI
IGI: Inferred from genetic interaction
15361870 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
14522834 MGI
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
23938297 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10331973 MGI
acts upstream of or within cell projection assembly IDA
IDA: Inferred from direct assay
12176888 MGI
acts upstream of or within digestive tract development IGI
IGI: Inferred from genetic interaction
23938297 MGI
involved in digestive tract development IMP
IMP: Inferred from mutant phenotype
10903171 MGI
involved in embryonic lung development IMP
IMP: Inferred from mutant phenotype
9374392 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
10331973 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
11803579 MGI
involved in lung alveolus development IMP
IMP: Inferred from mutant phenotype
9374392 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10331973 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
10331973 MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling IMP
IMP: Inferred from mutant phenotype
18559345 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
11940581 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
10331973 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19734317 MGI
located in microvillus IDA
IDA: Inferred from direct assay
12101409 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet-derived growth factor subunit A

  • PDGF A-chain

  • PDGF subunit A

  • platelet-derived growth factor A-chain

  • platelet-derived growth factor alpha polypeptide

Recombinant Pdgfa Proteins

Cat. No. Product Name Accession Purity
HY-P7277 PDGF-AA Protein, Mouse P20033 (S87-T211) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0889 Glycylglycine 99.90% Unkown
HY-D0889R Glycylglycine (Standard) 99.91% Unkown
HY-RS10250 PDGFA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174553 Human PDGFA mRNA / Unkown
HY-RS17304 Pdgfa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23759 Pdgfa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W040074 Glycylglycine hydrochloride hydrate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdgfa NCBI NCBI:5154