Nme1 - NME/NM23 nucleoside diphosphate kinase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 191575

Summary

Enables several functions, including DNA binding activity; gamma-tubulin binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including cellular response to glucose stimulus; response to cAMP; and response to testosterone. Located in several cellular components, including centrosome; mitochondrial outer membrane; and perinuclear region of cytoplasm. Colocalizes with intermediate filament. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to human NME1 (NME/NM23 nucleoside diphosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nme1 Products (1)

mRNA Protein Name
NM_138548.2 NP_612557.1 nucleoside diphosphate kinase A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12010125 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
17572440 RGD
enables gamma-tubulin binding IDA
IDA: Inferred from direct assay
11139339 RGD
enables intermediate filament binding IPI
IPI: Inferred from physical interaction
11082283 RGD
enables nucleoside diphosphate kinase activity IDA
IDA: Inferred from direct assay
11139339 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11302744 RGD
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
12010125 RGD
Biological Process GO Annotation Evidence References Source
involved in GTP biosynthetic process IDA
IDA: Inferred from direct assay
11139339 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
19367376 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
19367376 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11082283 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
18493952 RGD
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
12010125 RGD
involved in negative regulation of myeloid leukocyte differentiation IDA
IDA: Inferred from direct assay
7737424 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
10069391 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
19639176 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
11082283 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
19639176 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11082283 RGD
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
11139339 RGD
located in intermediate filament IDA
IDA: Inferred from direct assay
11082283 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
22817458 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11082283 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleoside diphosphate kinase A

  • NDK A

  • NDP kinase A

  • NDP kinase beta

  • expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase)

  • metastasis inhibition factor NM23

  • non-metastatic cells 1, protein (NM23A) expressed in

  • nucloside diphosphate kinase

  • tumor metast

Nme1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Nme1 Q05982 MEN1 Homo sapiens O00255-2
Y2H
11302744
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09371 NME1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09372 NME1-NME2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20309 Nme1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26817 Nme1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nme1 NCBI NCBI:4830