Twf1 - twinfilin actin binding protein 1 Gene

Also Known as A6; Ptk9; twinfilin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19230

Summary

Enables actin monomer binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein tyrosine kinase activity. Involved in barbed-end actin filament capping; positive regulation of cardiac muscle hypertrophy; and sequestering of actin monomers. Located in several cellular components, including filopodium; myofibril; and perinuclear region of cytoplasm. Colocalizes with ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TWF1 (twinfilin actin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Twf1 Products (3)

mRNA Protein Name
NM_001402809.1 NP_001389738.1 twinfilin-1 isoform 2
NM_001402810.1 NP_001389739.1 twinfilin-1 isoform 3
NM_008971.5 NP_032997.3 twinfilin-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin monomer binding IDA
IDA: Inferred from direct assay
12807912 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
12807912 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17360616 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
9249064 MGI
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
11604420 MGI
Biological Process GO Annotation Evidence References Source
involved in barbed-end actin filament capping IDA
IDA: Inferred from direct assay
18837697 MGI
involved in negative regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
12807912 MGI
involved in positive regulation of cardiac muscle hypertrophy IDA
IDA: Inferred from direct assay
20571053 MGI
involved in sequestering of actin monomers IDA
IDA: Inferred from direct assay
18837697 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
10669753 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12807912 MGI
located in filopodium IDA
IDA: Inferred from direct assay
12807912 MGI
located in myofibril IDA
IDA: Inferred from direct assay
18837697 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12807912 MGI
colocalizes with ruffle membrane IDA
IDA: Inferred from direct assay
12807912 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

twinfilin-1

  • PTK9 protein tyrosine kinase 9

  • actin monomer-binding protein

  • protein A6

  • protein tyrosine kinase 9

  • twinfilin, actin-binding protein, homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15279 TWF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18978 Twf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25467 Twf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Twf1 NCBI NCBI:5756