TWF1 - twinfilin actin binding protein 1 Gene

Also Known as A6; PTK9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5756

About TWF1

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:43,793,723-43,806,317 (from NCBI)

This gene has 11 transcripts (splice variants), 246 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 46.7), thyroid (RPKM 44.3) and 25 other tissues.

Summary

This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]

TWF1 Products (2)

mRNA Protein Name
NM_001242397.2 NP_001229326.1 twinfilin-1 isoform 1
NM_002822.5 NP_002813.3 twinfilin-1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10406962 GOA
enables actin binding IDA
IDA: Inferred from direct assay
28493397 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28493397 GOA
NOT enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
10406962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TWF1 Protein Structure

Cofilin_ADF

Cofilin_ADF: Cofilin/tropomyosin-type actin-binding protein (16 - 130)

Cofilin_ADF

Cofilin_ADF: Cofilin/tropomyosin-type actin-binding protein (190 - 287)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

twinfilin-1

  • A6 protein tyrosine kinase

Recombinant TWF1 Proteins

Cat. No. Product Name Accession Purity
HY-P77167 PTK9 Protein, Human Q12792-4 (M1-D252) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77168 PTK9 Protein, Human (His-GST) Q12792-4 (M1-D252) ≥ 80%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15279 TWF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18978 Twf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25467 Twf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TWF1 VGNC VGNC:36524
Canis familiaris TWF1 VGNC VGNC:48001
Rattus norvegicus TWF1 RGD RGD:1311872
Mus musculus TWF1 MGD MGI:1100520
Felis catus TWF1 VGNC VGNC:97675
Macaca mulatta TWF1 VGNC VGNC:79970
Others TWF1 NCBI