TWF1 - twinfilin actin binding protein 1 Gene

Homo sapiens

Also known as A6; PTK9

Gene ID: 5756 | Gene type: protein coding

About TWF1

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:43,793,723-43,806,317 (from NCBI)

This gene has 11 transcripts (splice variants), 246 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 46.7), thyroid (RPKM 44.3) and 25 other tissues.

Summary

This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]

TWF1 Products(2)

mRNA	Protein	Name
NM_001242397.2	NP_001229326.1	twinfilin-1 isoform 1
NM_002822.5	NP_002813.3	twinfilin-1 isoform 2

TWF1 Protein Structure

Cofilin_ADF

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

twinfilin-1

A6 protein tyrosine kinase

Recombinant TWF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77167	PTK9 Protein, Human	Q12792-4 (M1-D252)	≥95%
HY-P77168	PTK9 Protein, Human (His-GST)	Q12792-4 (M1-D252)	≥95%

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15279	TWF1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TWF1	VGNC	VGNC:36524
Canis familiaris	TWF1	VGNC	VGNC:48001
Rattus norvegicus	TWF1	RGD	RGD:1311872
Mus musculus	TWF1	MGD	MGI:1100520
Felis catus	TWF1	VGNC	VGNC:97675
Macaca mulatta	TWF1	VGNC	VGNC:79970
Others	TWF1	NCBI