Sfrp2 - secreted frizzled-related protein 2 Gene

Also Known as Sdf5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20319

Summary

Enables Wnt-protein binding activity; endopeptidase activator activity; and receptor ligand activity. Involved in several processes, including regulation of gene expression; regulation of protein phosphorylation; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; negative regulation of signal transduction; and regulation of endopeptidase activity. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; eye; and genitourinary system. Orthologous to human SFRP2 (secreted Frizzled related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp2 Products (1)

mRNA Protein Name
NM_009144.2 NP_033170.1 secreted frizzled-related protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
17462603 MGI
enables endopeptidase activator activity IDA
IDA: Inferred from direct assay
19079247 MGI
enables enzyme activator activity IDA
IDA: Inferred from direct assay
19079247 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9096311 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
20723538 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19850029 MGI
acts upstream of or within Wnt signaling pathway involved in somitogenesis IGI
IGI: Inferred from genetic interaction
18257070 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
16467359 MGI
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
18729207 MGI
involved in branching involved in blood vessel morphogenesis IDA
IDA: Inferred from direct assay
19458075 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18257070 MGI
acts upstream of cardiac muscle cell apoptotic process IDA
IDA: Inferred from direct assay
17251350 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
18729207 MGI
involved in cellular response to X-ray IDA
IDA: Inferred from direct assay
19778523 MGI
acts upstream of or within chondrocyte development IMP
IMP: Inferred from mutant phenotype
18729207 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
19079247 MGI
acts upstream of or within convergent extension involved in axis elongation IGI
IGI: Inferred from genetic interaction
18257070 MGI
acts upstream of or within development of primary male sexual characteristics IGI
IGI: Inferred from genetic interaction
19100252 MGI
acts upstream of or within digestive tract morphogenesis IGI
IGI: Inferred from genetic interaction
19300477 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
18729207 MGI
involved in hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
19778523 MGI
acts upstream of or within male gonad development IGI
IGI: Inferred from genetic interaction
19100252 MGI
acts upstream of mesodermal cell fate specification IGI
IGI: Inferred from genetic interaction
17462603 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
19850029 MGI
acts upstream of or within negative regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19850029 MGI
acts upstream of or within negative regulation of JUN kinase activity IGI
IGI: Inferred from genetic interaction
19300477 MGI
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
10654605 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17804636 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
17462603 MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process IDA
IDA: Inferred from direct assay
17251350 MGI
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
10980594 MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
17251350 MGI
involved in negative regulation of dermatome development IDA
IDA: Inferred from direct assay
10654605 MGI
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
9391078 MGI
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
10980594 MGI
acts upstream of or within negative regulation of mesodermal cell fate specification IGI
IGI: Inferred from genetic interaction
17462603 MGI
involved in negative regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10980594 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
19850029 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
19850029 MGI
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
19458075 MGI
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19001373 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18166153 MGI
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
10980594 MGI
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10980594 MGI
acts upstream of or within positive regulation of endopeptidase activity IDA
IDA: Inferred from direct assay
19079247 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
18166153 MGI
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
20723538 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20723538 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
18729207 MGI
involved in regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
9391078 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18729207 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18729207 MGI
acts upstream of or within regulation of establishment of planar polarity IGI
IGI: Inferred from genetic interaction
19300477 MGI
involved in regulation of midbrain dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
22290867 MGI
involved in regulation of neuron projection development IDA
IDA: Inferred from direct assay
22290867 MGI
involved in regulation of stem cell division IDA
IDA: Inferred from direct assay
19778523 MGI
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
19778523 MGI
involved in sclerotome development IEP
IEP: Inferred from expression pattern
10654605 MGI
acts upstream of or within somitogenesis IGI
IGI: Inferred from genetic interaction
16467359 MGI
acts upstream of stem cell fate specification IGI
IGI: Inferred from genetic interaction
17462603 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
9391078 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

secreted frizzled-related protein 2

  • SARP-1

  • sFRP-2

  • secreted apoptosis-related protein 1

  • secreted frizzled-related sequence protein 2

  • secreted frizzled-related sequence protein 5

  • stromal cell derived factor 5

Recombinant Sfrp2 Proteins

Cat. No. Product Name Accession Purity
HY-P74553 SFRP2 Protein, Mouse (HEK293, His) NP_033170.1 (L25-C295) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12775 SFRP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17992 Sfrp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24463 Sfrp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sfrp2 NCBI NCBI:6423