GPC2 - glypican 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 221914

About GPC2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,169,606-100,177,381 (from NCBI)

This gene has 5 transcripts (splice variants), 190 orthologues and 5 paralogues. Biased expression in testis (RPKM 5.5), skin (RPKM 2.9) and 7 other tissues.

Summary

Predicted to be involved in several processes, including positive regulation of neuron projection development; regulation of protein localization to membrane; and smoothened signaling pathway. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

GPC2 Products (1)

mRNA Protein Name
NM_152742.3 NP_689955.1 glypican-2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29162697 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPC2 Protein Structure

Glypican

Glypican: Glypican (10 - 551)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 579 a.a.
Protein Preferred Names Protein Names

glypican-2

  • cerebroglycan proteoglycan

Recombinant GPC2 Proteins

Cat. No. Product Name Accession Purity
HY-P78735 Glypican-2/GPC2 Protein, Human (HEK293, Fc) Q8N158 (S24-S553) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Keipert Syndrome

  • Nasodigitoacoustic Syndrome

  • KPTS

  • Nasodigitoacoustic Syndrome, Formerly
Omodysplasia

  • Omodysplasia Type 1

  • Omodysplasia 2
Central Corneal Ulcer
Simpson-Golabi-Behmel Syndrome, Type 1

  • Simpson-Golabi-Behmel Syndrome Type 1

  • Simpson-Golabi-Behmel Syndrome

  • SGBS1

  • Golabi-Rosen Syndrome

  • Simpson Dysmorphia Syndrome

  • Sgbs

  • Bulldog Syndrome

  • Dgsx

  • Sdys

  • Dysplasia Gigantism Syndrome, X-Linked

  • X-Linked Dysplasia Gigantism Syndrome

  • Dgsx Golabi-Rosen Syndrome

  • Sara Angers Syndrome

  • Sgb Syndrome

  • Mental Retardation-Overgrowth Syndrome

  • Simpson Dysplasia Syndrome

  • Simpson Syndrome

  • Simpson-Golabi-Behmel Syndrome 1

  • Dysplasia Gigantism Syndrome X-Linked
Hereditary Multiple Exostoses

  • Multiple Congenital Exostosis

  • Hereditary Multiple Exostoses 1

  • Hereditary Multiple Exostoses 2

  • Hereditary Multiple Exostoses 3

  • Multiple Exostosis Syndromes

  • Multiple Ostechondromas

  • Osteochondromatosis Syndrome

  • Exostoses Multiple Hereditary

  • Exostoses, Multiple Hereditary
Saul-Wilson Syndrome

  • Microcephalic Osteodysplastic Dysplasia

  • Microcephalic Osteodysplastic Dysplasia, Saul-Wilson Type

  • SWILS

  • Microcephalic Osteodysplastic Dysplasia Saul Wilson Type
Exostosis

  • Osteophyte

  • Exostoses

  • Orbital Exostosis

  • Exostosis Of Orbit

  • Bone Spur

  • Bony Outgrowth

  • Swimmer'S Exostosis

  • Osteophytes

  • External Exotoses

  • Cartilaginous Exostosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05627 GPC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18614 Gpc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25100 Gpc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990842 Anti-GPC-2 Antibody (CT3) Inhibitor 95% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPC2 VGNC VGNC:41372
Bos taurus GPC2 VGNC VGNC:29524
Macaca mulatta GPC2 VGNC VGNC:108411
Felis catus GPC2 VGNC VGNC:67404
Rattus norvegicus GPC2 RGD RGD:621363
Mus musculus GPC2 MGD MGI:1919201
Others GPC2 NCBI