HECW1 - HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Gene

Homo sapiens

Also known as NEDL1

Gene ID: 23072 | Gene type: protein coding

About HECW1

Cytogenetic location: 7p14.1-p13 Genomic coordinates (GRCh38): 7:43,112,647-43,566,001 (from NCBI)

This gene has 11 transcripts (splice variants), 229 orthologues and 24 paralogues. Biased expression in kidney (RPKM 3.0), brain (RPKM 2.6) and 3 other tissues.

Summary

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

HECW1 Products(2)

mRNA	Protein	Name
NM_001287059.2	NP_001273988.1	E3 ubiquitin-protein ligase HECW1 isoform b
NM_015052.5	NP_055867.3	E3 ubiquitin-protein ligase HECW1 isoform a

HECW1 Protein Structure

HECT

0
300
600
900
1200
1500
1606 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase HECW1

HECT type E3 ubiquitin ligase

Related Diseases

Diseases

Alias

Lung Papillary Adenocarcinoma

Papillary Lung Adenocarcinoma

Papillary Adenocarcinoma Of The Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06111	HECW1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HECW1	VGNC	VGNC:62786
Rattus norvegicus	HECW1	RGD	RGD:1561038
Bos taurus	HECW1	VGNC	VGNC:55052
Mus musculus	HECW1	MGD	MGI:2444115
Macaca mulatta	HECW1	VGNC	VGNC:73217
Canis familiaris	HECW1	VGNC	VGNC:41645

Name
Email *

	Sorry, but the email address you supplied was invalid.