HECW1 - HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Gene

Also Known as NEDL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23072

About HECW1

Cytogenetic location: 7p14.1-p13 Genomic coordinates (GRCh38): 7:43,112,647-43,566,001 (from NCBI)

This gene has 11 transcripts (splice variants), 229 orthologues and 24 paralogues. Biased expression in kidney (RPKM 3.0), brain (RPKM 2.6) and 3 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

HECW1 Products (2)

mRNA Protein Name
NM_001287059.2 NP_001273988.1 E3 ubiquitin-protein ligase HECW1 isoform b
NM_015052.5 NP_055867.3 E3 ubiquitin-protein ligase HECW1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HECW1 Protein Structure

C2

C2: C2 domain (212 - 301)

WW

WW: WW domain (831 - 860)

HECT

HECT: HECT-domain (ubiquitin-transferase) (1302 - 1605)

  • 0
  • 300
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  • 1200
  • 1500
  • 1606 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase HECW1

  • HECT type E3 ubiquitin ligase

HECW1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HECW1 Q76N89 VAX1 Homo sapiens Q5SQQ9-2
Y2H Array
32296183
Intra
HECW1 Q76N89 VAX1 Homo sapiens Q5SQQ9-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lung Papillary Adenocarcinoma

  • Papillary Lung Adenocarcinoma

  • Papillary Adenocarcinoma Of The Lung
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06111 HECW1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22549 Hecw1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29069 Hecw1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HECW1 VGNC VGNC:62786
Rattus norvegicus HECW1 RGD RGD:1561038
Bos taurus HECW1 VGNC VGNC:55052
Mus musculus HECW1 MGD MGI:2444115
Macaca mulatta HECW1 VGNC VGNC:73217
Canis familiaris HECW1 VGNC VGNC:41645
Others HECW1 NCBI