Hspa1a - heat shock protein family A (Hsp70) member 1A Gene

Also Known as HSP72; Hspa1; Hspa1b; HSP70-2; HSP70.1; HSP70.2; Hsp70-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24472

Summary

Predicted to enable several functions, including ATP binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including response to ethanol; response to ischemia; and response to unfolded protein. Located in membrane raft. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1B (heat shock protein family A (HSP70) member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Hspa1a Products (1)

mRNA Protein Name
NM_031971.2 NP_114177.2 heat shock 70 kDa protein 1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
16135962 RGD
enables protease binding IPI
IPI: Inferred from physical interaction
16397188 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9553041 RGD
Biological Process GO Annotation Evidence References Source
involved in defense response IDA
IDA: Inferred from direct assay
11820796 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
16397188 RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
16397188 RGD
NOT involved in negative regulation of myeloid cell apoptotic process IDA
IDA: Inferred from direct assay
10679071 RGD
involved in negative regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
15381648 RGD
involved in positive regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
10679071 RGD
involved in response to unfolded protein IMP
IMP: Inferred from mutant phenotype
8271311 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16609151 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16609151 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
14499952 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16135962 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heat shock 70 kDa protein 1A

  • HSP70-1/HSP70-2

  • HSP70.1/2

  • HSP70.1/HSP70.2

  • Heat shock 70 kDa protein 1

  • heat shock 70 kDa protein 1/2

  • heat shock 70 kDa protein 1A/1B

  • heat shock 70 kDa protein 1B

  • heat shock 70 kDa protein 2

  • heat shock 70kD protein 1A

  • heat shock protein 70-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162567 AP-4-139B 98.87% Unkown
HY-RS06424 HSPA1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18094 Hspa1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117252 HS-72 Inhibitor / Unkown
HY-RS24569 Hspa1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa1a NCBI NCBI:3303