HSPA1A - heat shock protein family A (Hsp70) member 1A Gene

Also Known as HSP70; HSP72; HSPA1; HSP70I; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP70-1A; HEL-S-103

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3303

About HSPA1A

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,815,543-31,817,942 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 142 orthologues and 13 paralogues.

Summary

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with Other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

HSPA1A Products (1)

mRNA	Protein	Name
NM_005345.6	NP_005336.3	heat shock 70 kDa protein 1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	23921388	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	21231916	GOA
enables ATP-dependent protein disaggregase activity	IDA IDA: Inferred from direct assay	23921388	GOA
enables C3HC4-type RING finger domain binding	IPI IPI: Inferred from physical interaction	25281747	GOA
enables G protein-coupled receptor binding	IDA IDA: Inferred from direct assay	12150907	GOA
enables death receptor agonist activity	IDA IDA: Inferred from direct assay	26183779	GOA
enables denatured protein binding	IPI IPI: Inferred from physical interaction	21909508	GOA
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	11785981	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables misfolded protein binding	IDA IDA: Inferred from direct assay	28842558	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9222587	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	15603737	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	17568691	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	24790089	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	9499401	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	9499401	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ATP metabolic process	IDA IDA: Inferred from direct assay	23921388	GOA
involved in cellular heat acclimation	IMP IMP: Inferred from mutant phenotype	21231916	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	9499401	GOA
involved in cellular response to unfolded protein	IMP IMP: Inferred from mutant phenotype	20625543	GOA
involved in chaperone-mediated protein complex assembly	IDA IDA: Inferred from direct assay	10811660	GOA
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	10205060	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17167422	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	9553041	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9553041	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	12150907	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	17167422	GOA
involved in negative regulation of inclusion body assembly	IDA IDA: Inferred from direct assay	15603737	GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	20625543	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	12150907	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9499401	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24613385	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of RNA splicing	IDA IDA: Inferred from direct assay	20625543	GOA
involved in positive regulation of endoribonuclease activity	IDA IDA: Inferred from direct assay	20625543	GOA
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17167422	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25281747	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of microtubule nucleation	IMP IMP: Inferred from mutant phenotype	27137183	GOA
involved in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24613385	GOA
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in protein refolding	IDA IDA: Inferred from direct assay	15603737	GOA
involved in protein refolding	IMP IMP: Inferred from mutant phenotype	27708256	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	21909508	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	27137183	GOA
involved in regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16809764	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in aggresome	IDA IDA: Inferred from direct assay	15885686	GOA
located in centriole	IDA IDA: Inferred from direct assay	24061851	GOA
located in centrosome	IDA IDA: Inferred from direct assay	27137183	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9553041	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	17568691	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	15603737	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	9553041	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10205060	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10205060	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA1A Protein Structure

HSP70

0
100
200
300
400
500
600
641 a.a.

Protein Preferred Names	Protein Names
heat shock 70 kDa protein 1A	HSP70-1/HSP70-2

HSPA1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HSPA1A	P0DMV8	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	HSPA1A	P0DMV8	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	HSPA1A	P0DMV8	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	HSPA1A	P0DMV8	PSMD10	Homo sapiens	O75832	Anti Tag CoIP	24338975
Intra	HSPA1A	P0DMV8	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950
Intra	HSPA1A	P0DMV8	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	HSPA1A	P0DMV8	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	HSPA1A	P0DMV8	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Cross	HSPA1A	P0DMV8	tetX	Clostridium tetani	P04958	Solid Phase Assay	24428437
Cross	HSPA1A	P0DMV8	HA	Influenza A virus	P04663	Solid Phase Assay	24428437

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSPA1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73105	HSP70/HSPA1B Protein, Human (SF9, His)	P0DMV9/NP_005337.2 (A2-D641)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P74877	HSP70/HSPA1A Protein, Human (HEK293, His)	P0DMV8-1/NP_005336.3 (A2-D641)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701004	HSP70/HSPA1A Protein, Human (E110D, His)	P0DMV8-1 (A2-D641, E110D)	≥ 95%, as determined by reducing SDS-PAGE.

HSPA1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85508	Hsp70(C-term) Antibody (YA5200)	WB, IP	Human
HY-P85654	Hsp70 Antibody (YA5346)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P86589	Hsp70 Antibody (YA6281)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Transient Cerebral Ischemia	Transient Ischemic Attack Transient Ischemic Attacks Tia Tia - Transient Ischaemic Attack Transient Cerebral Ischaemia Ischemic Attack, Transient Intermittent Cerebral Ischemia Tia - [Transient Ischaemic Attack] Intermittent Cerebral Ischaemia Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Ischemia	Acute Coronary Syndrome
Pulmonary Edema
Pneumoconiosis	Pneumoconioses Silicosis Nos Complicated Silicosis Fibrosis Of Lung With Silicosis Nodular Silicosis Pneumoconiosis Due To Silica Silicotic Fibrosis Of Lung Simple Silicosis Silicatosis Silicotic Lung Fibrosis Pneumoconiosis Due To Talc Pulmonary Talcosis Talc Lung Disease Talc Pneumoconiosis Talc Workers' Pneumoconiosis Talcosis Fibrosis Of Lung Due To Talc Asbestos Pneumoconiosis Amianthosis Asbestosis Lung Fibrosis With Asbestosis Pulmonary Asbestosis
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Acute Kidney Failure	Acute Renal Failure Acute Kidney Injury Renal Failure Acute Kidney Failure, Acute Pre-Renal Acute Kidney Injury Nontraumatic Acute Kidney Injury Aki - [Acute Kidney Injury] Arf - [Acute Kidney Failure] Acute Kidney Disease Acute Kidney Impairment Acute Ischaemic Renal Failure Acute Hypoxic Kidney Failure Acute Kidney Shutdown Acute Renal Oedema Acute Renal Impairment Acute Kidney Collapse Acute Necrotising Kidney Acute Renal Suppression
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162567	AP-4-139B		98.87%	Unkown
HY-RS06424	HSPA1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18094	Hspa1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-117252	HS-72	Inhibitor	/	Unkown
HY-RS24569	Hspa1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HSPA1A	RGD	RGD:1593284
Mus musculus	HSPA1A	MGD	MGI:96244