Sparc - secreted protein acidic and cysteine rich Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24791

Summary

Enables calcium ion binding activity. Involved in several processes, including animal organ development; response to L-ascorbic acid; and response to lead ion. Located in several cellular components, including extracellular space; nucleus; and vesicle. Is active in glutamatergic synapse. Biomarker of diabetic angiopathy; membranoproliferative glomerulonephritis; membranous glomerulonephritis; myocardial infarction; and stomach carcinoma. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Apr 2022]

Sparc Products (1)

mRNA Protein Name
NM_012656.2 NP_036788.1 SPARC precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
2322281 RGD
Biological Process GO Annotation Evidence References Source
involved in heart development IEP
IEP: Inferred from expression pattern
8287436 RGD
involved in inner ear development IEP
IEP: Inferred from expression pattern
11335086 RGD
involved in lung development IMP
IMP: Inferred from mutant phenotype
7654384 RGD
involved in ossification IEP
IEP: Inferred from expression pattern
12365801 RGD
involved in regulation of synapse organization EXP
EXP: Inferred from Experiment
21788491 RGD
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
21788491 RGD
involved in response to L-ascorbic acid IEP
IEP: Inferred from expression pattern
9495521 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
10703670 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
9232954 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
11897705 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
10703670 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
11371715 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
9232954 RGD
involved in response to gravity IEP
IEP: Inferred from expression pattern
17384275 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
1412468 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
10703670 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15779007 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
2322281 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
21788491 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21788491 RGD
is active in synapse EXP
EXP: Inferred from Experiment
16507876 RGD
is active in synapse IDA
IDA: Inferred from direct assay
16507876 RGD
located in vesicle IDA
IDA: Inferred from direct assay
18758911 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SPARC

  • BM-40

  • ON

  • Secreted acidic cystein-rich glycoprotein (osteonectin)

  • basement-membrane protein 40

  • osteonectin

  • secreted acidic cysteine rich glycoprotein

  • secreted protein acidic and rich in cysteine

  • secreted protein, acidic, cysteine-rich (osteonectin)

Recombinant Sparc Proteins

Cat. No. Product Name Accession Purity
HY-P73420 SPARC Protein, Rat (HEK293, His) P16975 (A18-I301) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13631 SPARC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10335 SPARC (119-122) (mouse) / Unkown
HY-RS16848 Sparc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23289 Sparc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sparc NCBI NCBI:6678