Glul - glutamate-ammonia ligase Gene

Also Known as Glns

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24957

Summary

Enables several functions, including anion binding activity; dynein light chain binding activity; and metal ion binding activity. Involved in glutamine metabolic process; positive regulation of cell communication; and positive regulation of epithelial cell proliferation. Located in several cellular components, including myelin sheath; perikaryon; and rough endoplasmic reticulum. Part of protein-containing complex. Used to study obesity; temporal lobe epilepsy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Orthologous to human GLUL (glutamate-ammonia Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Glul Products (2)

mRNA Protein Name
NM_001393804.1 NP_001380733.1 glutamine synthetase
NM_017073.4 NP_058769.4 glutamine synthetase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
28323 RGD
enables dynein light chain binding IPI
IPI: Inferred from physical interaction
14760703 RGD
enables glutamate binding IDA
IDA: Inferred from direct assay
28323 RGD
enables glutamine synthetase activity IDA
IDA: Inferred from direct assay
28323 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
28323 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
28323 RGD
enables manganese ion binding IDA
IDA: Inferred from direct assay
28323 RGD
enables nickel cation binding IDA
IDA: Inferred from direct assay
21254280 RGD
Biological Process GO Annotation Evidence References Source
involved in ammonia assimilation cycle IDA
IDA: Inferred from direct assay
28323 RGD
involved in glutamate metabolic process IDA
IDA: Inferred from direct assay
4403443 RGD
involved in glutamine biosynthetic process IDA
IDA: Inferred from direct assay
28323 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
9915876 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
12575909 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
10696145 RGD
Cellular Component GO Annotation Evidence References Source
NOT located in axon terminus IDA
IDA: Inferred from direct assay
31966 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
6105901 RGD
located in cell projection IDA
IDA: Inferred from direct assay
31966 RGD
located in myelin sheath IDA
IDA: Inferred from direct assay
17960831 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
31966 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
28323 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamine synthetase

  • GS

  • Glutamine synthetase (glutamate-ammonia ligase)

  • glutamate decarboxylase

  • glutamate-ammonia ligase (glutamine synthase)

  • glutamate-ammonia ligase (glutamine synthetase)

  • glutamine synthetase 1

  • palmitoyltransferase GLUL

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05509 GLUL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17491 Glul Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23948 Glul Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glul NCBI NCBI:2752