Cd59 - CD59 molecule Gene

Also Known as Cd59a; Cd59b; MACIF; MACIP; MAC-IP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25407

Summary

Enables complement binding activity. Involved in several processes, including negative regulation of activation of membrane attack complex; negative regulation of complement-dependent cytotoxicity; and positive regulation of T cell proliferation. Located in compact myelin; extracellular space; and sarcolemma. Used to study anterior uveitis; colorectal carcinoma; glomerulonephritis; nephrosis; and neuromyelitis optica. Biomarker of acute necrotizing pancreatitis; diabetic retinopathy; and myocardial infarction. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian Cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Cd59 Products (1)

mRNA Protein Name
NM_012925.2 NP_037057.1 CD59 glycoprotein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables complement binding IDA
IDA: Inferred from direct assay
9038722 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of activation of membrane attack complex IDA
IDA: Inferred from direct assay
15843577 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10807586 RGD
involved in negative regulation of complement-dependent cytotoxicity IMP
IMP: Inferred from mutant phenotype
28212662 RGD
involved in positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
8621904 RGD
Cellular Component GO Annotation Evidence References Source
located in compact myelin IDA
IDA: Inferred from direct assay
12153479 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
9038722 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
7515561 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD59 glycoprotein

  • CD59 antigen

  • CD59 molecule, complement regulatory protein

  • CD59b moleucle, complement regulatory protein

  • Cb59b molecule

  • MAC-inhibitory protein

  • membrane attack complex inhibition factor

  • protectin

Recombinant Cd59 Proteins

Cat. No. Product Name Accession Purity
HY-P75390 CD59 Protein, Rat (HEK293, His) P27274 (L23-N100) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75391 CD59 Protein, Rat (HEK293, Fc) P27274 (L23-N100) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02257 CD59 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990356 Anti-CD59 Antibody 99.82% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd59 NCBI NCBI:966
Macaca fascicularis Cd59 NCBI NCBI:101867071
Mus musculus Cd59 NCBI