CD59 Protein, Rat (HEK293, Fc)

The CD59 protein is a potent inhibitor of the complement membrane attack complex (MAC) and exerts regulatory control at or after the C5b-8 stage. Its critical role makes CD59 a key regulator in the complement system, preventing overactivation and associated membrane damage. CD59 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD59 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD59 Protein, Rat (HEK293, Fc) is 100 a.a., with molecular weight of ~40 & 43 kDa, respectively.

CD59 Protein emerges as a potent inhibitor of the complement membrane attack complex (MAC) action, exerting its regulatory influence at or after the C5b-8 stage of MAC assembly. This key role positions CD59 as a crucial modulator in the complement system, preventing excessive activation and the subsequent membrane damage associated with uncontrolled MAC formation. By targeting specific stages of the MAC assembly process, CD59 plays a pivotal role in maintaining the delicate balance of complement activation, highlighting its significance in the immune response and safeguarding cellular integrity from complement-mediated damage.

Rat

HEK293

C-hFc

P27274 (M1-N100)

25407  [NCBI]

Approximately 40&43 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.