Ptprz1 - protein tyrosine phosphatase, receptor type Z1 Gene

Also Known as Ptpz; RPTPbeta; PTPzeta-A; PTPzeta-B; PTPzeta-S

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25613

Summary

Enables Fibroblast Growth Factor binding activity and protein tyrosine Phosphatase activity. Involved in several processes, including nervous system development; positive regulation of cell migration; and regulation of dendrite development. Located in several cellular components, including lamellipodium; perineuronal net; and ruffle membrane. Is intrinsic component of plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of amyotrophic lateral sclerosis; middle cerebral artery infarction; status epilepticus; temporal lobe epilepsy; and visual epilepsy. Orthologous to human PTPRZ1 (protein tyrosine Phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Apr 2022]

Ptprz1 Products (2)

mRNA Protein Name
NM_001170685.1 NP_001164156.1 receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor
NM_013080.2 NP_037212.2 receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fibroblast growth factor binding IPI
IPI: Inferred from physical interaction
9705269 RGD
enables phosphatase activity IDA
IDA: Inferred from direct assay
17646177 RGD
enables phosphatase activity IMP
IMP: Inferred from mutant phenotype
30667096 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8702927 RGD
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
11381105 RGD
Biological Process GO Annotation Evidence References Source
involved in axonal fasciculation IDA
IDA: Inferred from direct assay
16150606 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
10906718 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9809586 RGD
involved in negative regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
12821372 RGD
involved in negative regulation of dendrite development IDA
IDA: Inferred from direct assay
11431463 RGD
involved in neuron development IEP
IEP: Inferred from expression pattern
15708477 RGD
involved in oligodendrocyte differentiation IEP
IEP: Inferred from expression pattern
8812065 RGD
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
16814777 RGD
involved in positive regulation of Schwann cell migration IMP
IMP: Inferred from mutant phenotype
11520897 RGD
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
11340082 RGD
involved in positive regulation of dendrite development IDA
IDA: Inferred from direct assay
8625816 RGD
involved in positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
9705269 RGD
involved in positive regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
9660874 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
8702927 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
30667096 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
8625816 RGD
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
11381105 RGD
involved in regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
12684467 RGD
involved in visual learning IEP
IEP: Inferred from expression pattern
12737936 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15708477 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15708477 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
15982644 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
15708477 RGD
located in filopodium IDA
IDA: Inferred from direct assay
9660874 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15982644 RGD
located in growth cone IDA
IDA: Inferred from direct assay
8702927 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
9660874 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8702927 RGD
located in perineuronal net IDA
IDA: Inferred from direct assay
16644727 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
16814777 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
15982644 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
15982644 RGD
located in ruffle membrane IDA
IDA: Inferred from direct assay
11381105 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase zeta

  • 3F8 chondroitin sulfate proteoglycan

  • 3H1 keratan sulfate proteoglycan

  • 6B4 proteoglycan

  • PTP zeta

  • R-PTP-zeta

  • protein tyrosine phosphatase, receptor-type, Z polypeptide 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123856 MY10 99.86% Unkown
HY-RS11452 PTPRZ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17478 Ptprz1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23936 Ptprz1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprz1 NCBI NCBI:5803