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Hnf4a - hepatocyte nuclear factor 4, alpha Gene

Also Known as Hnf4; Hnf4alpha

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25735

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; long-chain fatty acid binding activity; and long-chain fatty acyl-CoA binding activity. Involved in several processes, including hepatocyte differentiation; negative regulation of peptidyl-tyrosine phosphorylation; and regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Biomarker of hepatocellular carcinoma and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Hnf4a Products (3)

mRNA	Protein	Name
NM_001270931.1	NP_001257860.1	hepatocyte nuclear factor 4-alpha isoform 2
NM_001270933.1	NP_001257862.1	hepatocyte nuclear factor 4-alpha isoform 3
NM_022180.2	NP_071516.2	hepatocyte nuclear factor 4-alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20735474	RGD
enables arachidonate binding	IDA IDA: Inferred from direct assay	11940586	RGD
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16640558	RGD
enables fatty acid binding	IPI IPI: Inferred from physical interaction	15870076	RGD
enables fatty-acyl-CoA binding	IPI IPI: Inferred from physical interaction	15870076	RGD
enables long-chain fatty acyl-CoA binding	IDA IDA: Inferred from direct assay	11940586	RGD
enables long-chain fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	15870076	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14530276	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	12205093	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12205093	RGD
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	2279702	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12089346	RGD
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	16893891	RGD
enables stearic acid binding	IDA IDA: Inferred from direct assay	11940586	RGD
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	19651776	RGD
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	12205093	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in acyl-CoA metabolic process	IDA IDA: Inferred from direct assay	15870076	RGD
involved in cell differentiation	IMP IMP: Inferred from mutant phenotype	16563856	RGD
involved in cell-cell junction organization	IDA IDA: Inferred from direct assay	12749857	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	24177414	RGD
involved in establishment of tissue polarity	IDA IDA: Inferred from direct assay	12749857	RGD
involved in hepatocyte differentiation	IEP IEP: Inferred from expression pattern	19621519	RGD
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16584384	RGD
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	12036449	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15541721	RGD
involved in negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	15541721	RGD
involved in negative regulation of non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	16584384	RGD
involved in negative regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	16584384	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19651776	RGD
involved in positive regulation of fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	16800817	RGD
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	12089346	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	12205093	RGD
involved in positive regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	16893891	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20735474	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16893891	RGD
involved in regulation of microvillus assembly	IMP IMP: Inferred from mutant phenotype	17178913	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	16799975	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	16570165	RGD
involved in response to glucose	IDA IDA: Inferred from direct assay	16800817	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11679969	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	17640976	RGD
involved in response to trichostatin A	IDA IDA: Inferred from direct assay	12205093	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16799975	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	19651776	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hepatocyte nuclear factor 4-alpha	HNF-4-alpha TCF-14 alpha transcription factor 4 hepatic nuclear factor 4, alpha nuclear receptor subfamily 2 group A member 1 transcription factor 14 transcription factor HNF-4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176847	DHQZ-17		99.58%	Unkown
HY-RS06257	HNF4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17608	Hnf4a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24068	Hnf4a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06255	HNF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnf4a	NCBI	NCBI:3172