DSTYK - dual serine/threonine and tyrosine protein kinase Gene

Also Known as RIP5; RIPK5; SPG23; CAKUT1; DustyPK; HDCMD38P

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25778

About DSTYK

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,142,505-205,211,702 (from NCBI)

This gene has 3 transcripts (splice variants), 211 orthologues, 6 paralogues and is associated with 6 phenotypes. Ubiquitous expression in brain (RPKM 8.1), bone marrow (RPKM 6.5) and 25 other tissues.

Summary

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

DSTYK Products (2)

mRNA	Protein	Name
NM_015375.3	NP_056190.1	dual serine/threonine and tyrosine protein kinase isoform 1
NM_199462.3	NP_955749.1	dual serine/threonine and tyrosine protein kinase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	36931259	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: Inferred from direct assay	23862974	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	28157540	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23862974	GOA
involved in positive regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23862974	GOA
involved in positive regulation of kinase activity	IMP IMP: Inferred from mutant phenotype	23862974	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	23862974	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	23862974	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23862974	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DSTYK Protein Structure

Pkinase

0
200
400
600
800
929 a.a.

Protein Preferred Names	Protein Names
dual serine/threonine and tyrosine protein kinase	RIP-homologous kinase

DSTYK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DSTYK	Q6XUX3	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Congenital Anomalies Of Kidney And Urinary Tract 1	CAKUT1 Renal Hypodysplasia, Nonsyndromic, 1 Rhdns1 Congenital Anomalies Of The Kidney And Urinary Tract 1 Non-Syndromic Renal Hypodysplasia 1 Kidney And Urinary Tract, Anomalies, Congenital, Susceptibility To, Type 1
Spastic Paraplegia 23, Autosomal Recessive	Lison Syndrome SPG23 Spastic Paraparesis, Vitiligo, Premature Graying, Characteristic Facies Spastic Paraplegia 23 Spastic Paraplegia With Pigmentary Abnormalities Autosomal Recessive Spastic Paraplegia Type 23 Spg 23 Spastic Paraplegia And Pigmentary Abnormalities Spastic Paraplegia Vitiligo Premature Graying And Characteristic Facies Spastic Paraparesis-Vitiligo-Premature Graying-Characteristic Facies Syndrome
Hereditary Spastic Paraplegia 23	Lison Syndrome Spastic Paraparesis-Vitiligo-Premature Graying-Characteristic Facies Syndrome Spastic Paraplegia 23 Spastic Paraplegia With Pigmentary Abnormalities Spg23
Renal Hypodysplasia/Aplasia 3	RHDA3 Renal Agenesis, Unilateral Unilateral Renal Agenesis
Posterior Urethral Valves	Posterior Urethral Valve Congenital Posterior Urethral Valves Puv
Paraplegia	Paraplegia, Lower Severe Or Complete Loss Of Motor Function In The Lower Extremities And Lower Portions Of The Trunk
Spastic Paraplegia 74, Autosomal Recessive	SPG74 Hereditary Spastic Paraplegia 74 Autosomal Recessive Spastic Paraplegia 74 Autosomal Recessive Spastic Paraplegia Type 74 Paraplegia, Spastic, Autosomal Recessive, Type 74
Congenital Anomalies Of Kidney And Urinary Tract 2	CAKUT2 Ureteropelvic Junction Obstruction Multicystic Renal Dysplasia, Bilateral Pelviureteric Junction Obstruction Pujo Hydronephrosis Due To Pujo Upjo Mcrd Congenital Anomalies Of The Kidney And Urinary Tract 2 Mrd Pelvi-Ureteric Junction Obstruction Kidney And Urinary Tract, Anomalies, Congenital, Type 2 Obstruction Of Pelviureteric Junction
Bilateral Renal Aplasia
Vacterl Association, X-Linked, With Or Without Hydrocephalus	VACTERLX X-Linked Vacterl Association Vacterl-H, X-Linked Vacterl Association, X-Linked Vacterl Association, X-Linked With Or Without Hydrocephalus Vacterl Association X-Linked With Or Without Hydrocephalus Vacterl Syndrome Vertebral Anal Tracheoesophageal Esophageal Radial Anomalies X-Linked Vacterl-H Vacterl Association Vacterl Association With Hydrocephalus
Solitary Fibrous Tumor/Hemangiopericytoma	Sft/Hpc
Oligomeganephronia	Oligomeganephronic Renal Hypoplasia Oligomeganephronic Hypoplasia Of Kidney
Myopathy, Myofibrillar, 8	Myofibrillar Myopathy 8 MFM8 Myopathy, Myofibrillar, Type 8
Myopathy, Myofibrillar, 7	Myofibrillar Myopathy 7 MFM7 Kyphosis-Lateral Tongue Atrophy-Myofibrillar Myopathy Syndrome Myopathy, Myofibrillar, Type 7
Myopathy, Centronuclear, 5	CNM5 Centronuclear Myopathy 5 Myopathy, Centronuclear, Type 5
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Cardiomyopathy, Dilated, 1e	Left Ventricular Noncompaction 9 Left Ventricular Noncompaction 5 Dilated Cardiomyopathy 1e Dilated Cardiomyopathy 1s CMD1E Cdcd2 Cardiomyopathy, Dilated, 1y CMD1Y Cardiomyopathy, Dilated, 1s CMD1S Dilated Cardiomyopathy 1y Dilated Cardiomyopathy With Conduction Defect 2 Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Defect 2 Cardiomyopathy Dilated With Conduction Defect Type 2 Cardiomyopathy, Dilated 1e Cardiomyopathy, Dilated 1s Cardiomyopathy, Dilated 1y Left Ventricular Non-Compaction 5 LVNC5 Left Ventricular Non-Compaction 9 LVNC9 Cardiomyopathy, Dilated, Type 1e Cardiomyopathy, Dilated, Type 1s Cardiomyopathy, Dilated, Type 1y
Vesicoureteral Reflux	Vesico-Ureteral Reflux
Renal Hypodysplasia/Aplasia 1	Renal Agenesis Renal Adysplasia Renal Aplasia RHDA1 Hereditary Renal Aplasia Hra Hereditary Urogenital Adysplasia Hypodysplasia/Aplasia, Renal, Type 1 Congenital Absence Of Kidneys Syndrome Congenital Absence Of Kidney Aplastic Kidney
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04030	DSTYK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22473	Dstyk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28996	Dstyk Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DSTYK	MGD	MGI:1925064
Rattus norvegicus	DSTYK	RGD	RGD:735051
Felis catus	DSTYK	VGNC	VGNC:61641
Macaca mulatta	DSTYK	VGNC	VGNC:71922
Canis familiaris	DSTYK	VGNC	VGNC:54269
Bos taurus	DSTYK	VGNC	VGNC:28227
Others	DSTYK	NCBI