CHRDL2 - chordin like 2 Gene

Also Known as BNF1; CHL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25884

About CHRDL2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,696,429-74,731,426 (from NCBI)

This gene has 9 transcripts (splice variants), 118 orthologues and 19 paralogues. Biased expression in gall bladder (RPKM 39.8), appendix (RPKM 39.3) and 4 other tissues.

Summary

This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human Activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

CHRDL2 Products (7)

mRNA Protein Name
NM_001278473.3 NP_001265402.1 chordin-like protein 2 isoform 2 precursor
NM_001304390.2 NP_001291319.1 chordin-like protein 2 isoform 3
NM_001304391.2 NP_001291320.1 chordin-like protein 2 isoform 4
NM_001304415.2 NP_001291344.1 chordin-like protein 2 isoform 5
NM_001304416.2 NP_001291345.1 chordin-like protein 2 isoform 6
NM_001304417.2 NP_001291346.1 chordin-like protein 2 isoform 7
NM_015424.6 NP_056239.3 chordin-like protein 2 isoform 1 precursor

CHRDL2 Protein Structure

VWC

VWC: von Willebrand factor type C domain (33 - 95)

VWC

VWC: von Willebrand factor type C domain (111 - 174)

VWC

VWC: von Willebrand factor type C domain (252 - 314)

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  • 400
  • 429 a.a.
Protein Preferred Names Protein Names

chordin-like protein 2

  • breast tumor novel factor 1

Related Diseases

Diseases Alias
Immunodeficiency 36

  • IMD36

  • Activated Phosphoinositide 3-Kinase Delta Syndrome 2

  • Immunodeficiency, Type 36
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02658 CHRDL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20539 Chrdl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27047 Chrdl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CHRDL2 RGD RGD:1306179
Bos taurus CHRDL2 VGNC VGNC:27317
Canis familiaris CHRDL2 VGNC VGNC:39230
Felis catus CHRDL2 VGNC VGNC:60872
Macaca mulatta CHRDL2 VGNC VGNC:71081
Mus musculus CHRDL2 MGD MGI:1916371
Others CHRDL2 NCBI