PLEKHG3 - pleckstrin homology and RhoGEF domain containing G3 Gene

Also Known as ARHGEF43; KIAA0599

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26030

About PLEKHG3

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,704,424-64,750,249 (from NCBI)

This gene has 10 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in endometrium (RPKM 8.9), kidney (RPKM 8.6) and 25 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHG3 Products (1)

mRNA Protein Name
NM_001308147.2 NP_001295076.1 pleckstrin homology domain-containing family G member 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
27555588 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
27555588 GOA
involved in regulation of establishment of cell polarity IDA
IDA: Inferred from direct assay
27555588 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHG3 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (97 - 271)

PH

PH: PH domain (315 - 393)

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  • 200
  • 400
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  • 1000
  • 1219 a.a.
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family G member 3

  • PH domain-containing family G member 3

Related Diseases

Diseases Alias
Blepharocheilodontic Syndrome 1

  • Blepharocheilodontic Syndrome

  • Bcd Syndrome

  • Elschnig Syndrome

  • Clefting, Ectropion, And Conical Teeth

  • Lagophthalmia With Bilateral Cleft Lip And Palate

  • Blepharo-Cheilo-Odontic Syndrome

  • Bcds

  • Ectropion, Inferior, With Cleft Lip And/Or Palate

  • Blepharo-Cheilo-Dontic Syndrome

  • BCDS1

  • Ectropion Inferior Cleft Lip And Or Palate

  • Clefting-Ectropion-Conical Teeth Syndrome

  • Ectropion Inferior-Cleft Lip And/Or Palate Syndrome

  • Lagophthalmia-Cleft Lip And Palate Syndrome

  • Blepharocheilodontic Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10691 PLEKHG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22017 Plekhg3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28535 Plekhg3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLEKHG3 VGNC VGNC:33016
Macaca mulatta PLEKHG3 VGNC VGNC:76082
Rattus norvegicus PLEKHG3 RGD RGD:1308089
Felis catus PLEKHG3 VGNC VGNC:64228
Canis familiaris PLEKHG3 VGNC VGNC:44678
Mus musculus PLEKHG3 MGD MGI:2388284
Others PLEKHG3 NCBI