GCKR - glucokinase regulator Gene

Also Known as GKRP; FGQTL5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2646

About GCKR

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,496,839-27,523,684 (from NCBI)

This gene has 6 transcripts (splice variants), 141 orthologues and is associated with 1 phenotype. Biased expression in liver (RPKM 19.0), stomach (RPKM 3.8) and 3 other tissues.

Summary

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits Glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]

GCKR Products (1)

mRNA Protein Name
NM_001486.4 NP_001477.2 glucokinase regulatory protein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables fructose-6-phosphate binding IDA
IDA: Inferred from direct assay
14627435 GOA
enables glucose sensor activity IDA
IDA: Inferred from direct assay
14627435 GOA
enables kinase inhibitor activity IDA
IDA: Inferred from direct assay
14627435 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11522786 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of glucokinase activity IDA
IDA: Inferred from direct assay
23621087 GOA
involved in response to fructose IDA
IDA: Inferred from direct assay
14627435 GOA
involved in response to glucose IDA
IDA: Inferred from direct assay
14627435 GOA
involved in triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
19526250 GOA
involved in urate metabolic process IMP
IMP: Inferred from mutant phenotype
19503597 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucokinase regulatory protein

  • glucokinase (hexokinase 4) regulator

GCKR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GCKR Q14397 GCK Homo sapiens P35557
Phage Display
11522786
Intra
GCKR Q14397 GCK Homo sapiens P35557
ELISA
11522786
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GCKR Proteins

Cat. No. Product Name Accession Purity
HY-P71822 GCKR Protein, Human (P.pastoris, His) Q14397 (M1-Q625) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Fasting Plasma Glucose Level Quantitative Trait Locus 5

  • Fasting Plasma Glucose Level Qtl 5

  • FGQTL5
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Hyperglycemia
Maturity-Onset Diabetes Of The Young, Type 2

  • Maturity-Onset Diabetes Of The Young Type 2

  • MODY2

  • Mody Glucokinase-Related

  • Mody Type 2

  • Mody, Type 2

  • Mody, Glucokinase-Related

  • Mody, Type Ii

  • Maturity-Onset Diabetes Of The Young 2

  • Mody-2

  • Diabetes Of The Young, Maturity-Onset, Type 2

  • Diabetes Mellitus Autosomal Dominant Type Ii
Hypoglycemia

  • Hypoglycaemia

  • Low Blood Sugar

  • Hypoglycaemia Nos

  • Spontaneous Hypoglycaemia

  • Nondiabetic Hypoglycaemia

  • Hypoglycaemic Disorder Nos

  • Hypoglycaemic Syndrome
Hyperinsulinism

  • Hyperinsulinemia
Non-Alcoholic Fatty Liver Disease

  • Fatty Liver

  • Non-Alcoholic Fatty Liver

  • Nafld

  • Nonalcoholic Fatty Liver Disease

  • Nonalcoholic Steatohepatitis

  • Steatosis

  • Nafl

  • Nash

  • Non-Alcoholic Steatohepatitis

  • Susceptibility To Nonalcoholic Fatty Liver Disease

  • Steatohepatitis

  • Fatty Degeneration

  • Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

  • Nafld Without Nash

  • Nafld Without Mention Of Nash
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Fructosuria, Essential

  • Essential Fructosuria

  • Ketohexokinase Deficiency

  • Fructosuria

  • Hepatic Fructokinase Deficiency

  • Fructokinase Deficiency

  • FRUCT

  • Deficiency Of Fructokinase
Permanent Neonatal Diabetes Mellitus

  • Pndm

  • Permanent Diabetes Mellitus Of Infancy

  • Pdmi

  • Neonatal Diabetes Mellitus, Permanent
Hyperinsulinemic Hypoglycemia

  • Nesidioblastosis

  • Islet Cell Hyperplasia

  • Persistent Hyperinsulinemia Hypoglycemia Of Infancy

  • Hyperinsulinemic Hypoglycaemia
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diabetes Mellitus

  • Diabetes
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05332 GCKR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08083 MAP4K5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08084 Map4k5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19603 Gckr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26099 Gckr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GCKR RGD RGD:2671
Macaca mulatta GCKR VGNC VGNC:72902
Canis familiaris GCKR VGNC VGNC:97197
Mus musculus GCKR MGD MGI:1096345
Others GCKR NCBI