NR6A1 - nuclear receptor subfamily 6 group A member 1 Gene

Also Known as RTR; GCNF; NR61; hRTR; CT150; GCNF1; hGCNF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2649

About NR6A1

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,517,275-124,771,311 (from NCBI)

This gene has 5 transcripts (splice variants) and 227 orthologues. Biased expression in testis (RPKM 11.0), thyroid (RPKM 1.5) and 7 other tissues.

Summary

This gene encodes an Orphan Nuclear Receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

NR6A1 Products (4)

mRNA Protein Name
NM_001278546.2 NP_001265475.1 nuclear receptor subfamily 6 group A member 1 isoform 4
NM_001410996.1 NP_001397925.1 nuclear receptor subfamily 6 group A member 1 isoform 5
NM_001489.5 NP_001480.3 nuclear receptor subfamily 6 group A member 1 isoform 2
NM_033334.4 NP_201591.2 nuclear receptor subfamily 6 group A member 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR6A1 Protein Structure

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (59 - 127)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (282 - 455)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
Protein Preferred Names Protein Names

nuclear receptor subfamily 6 group A member 1

  • retinoic acid receptor-related testis-associated receptor

NR6A1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84587 NR6A1 Antibody (YA4284) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P84587A NR6A1 Antibody (YA4284)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Embryonal Carcinoma

  • Embryonal Neoplasm

  • Embryonal Cancer

  • Primary Extragonadal Embryonal Carcinoma

  • Embryo Neoplasm

  • Carcinoma Embryonal

  • Cancer Embryonal

  • Carcinoma, Embryonal

  • Extragonadal Embryonal Carcinoma

  • Cancer, Embryonal
Teratocarcinoma

  • Mixed Embryonal Carcinoma And Teratoma
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
46,Xy Sex Reversal

  • Swyer Syndrome

  • Pure Gonadal Dysgenesis 46,Xy

  • Gonadal Dysgenesis, Xy Female Type

  • Gonadal Dysgenesis, 46,Xy

  • 46,Xy Cgd

  • 46,Xy Complete Gonadal Dysgenesis

  • 46,Xy Pure Gonadal Dysgenesis

  • 46 Xy Gonadal Dysgenesis

  • 46, Xy Cgd

  • 46, Xy Complete Gonadal Dysgenesis

  • 46, Xy Pure Gonadal Dysgenesis

  • Xy Pure Gonadal Dysgenesis

  • Female With 46,Xy Karyotype

  • Xy Females
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09555 NR6A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22688 Nr6a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29202 Nr6a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NR6A1 VGNC VGNC:32250
Canis familiaris NR6A1 VGNC VGNC:49931
Macaca mulatta NR6A1 VGNC VGNC:75522
Rattus norvegicus NR6A1 RGD RGD:1564740
Felis catus NR6A1 VGNC VGNC:68558
Mus musculus NR6A1 MGD MGI:1352459
Others NR6A1 NCBI