Nlrc3 - NLR family, CARD domain containing 3 Gene

Also Known as CLR16.2; mFLJ00348; D230007K08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268857

Summary

Enables phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of cytokine production; and negative regulation of defense response. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling; regulation of protein ubiquitination; and response to lipopolysaccharide. Predicted to be located in centriolar satellite; intracellular membrane-bounded organelle; and perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human NLRC3 (NLR family CARD domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlrc3 Products (2)

mRNA Protein Name
NM_001081280.2 NP_001074749.1 protein NLRC3 isoform 1
NM_175547.4 NP_780756.1 protein NLRC3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables molecular function inhibitor activity IDA
IDA: Inferred from direct assay
22863753 MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding IDA
IDA: Inferred from direct assay
27951586 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22863753 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22863753 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
22863753 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
22863753 MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22863753 MGI
involved in negative regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
24560620 MGI
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
27951586 MGI
involved in negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
27951586 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
24560620 MGI
involved in negative regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
24560620 MGI
involved in negative regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
24560620 MGI
involved in negative regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
24560620 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
22863753 MGI
involved in negative regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
22863753 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
22863753 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
27951586 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
22863753 MGI
acts upstream of or within regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
22863753 MGI
acts upstream of or within regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
22863753 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
22863753 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein NLRC3

  • caterpillar 16.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0921 Dihydromethysticin 99.71% Unkown
HY-RS09346 NLRC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20066 Nlrc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26570 Nlrc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlrc3 NCBI NCBI:197358