IZUMO1 - izumo sperm-oocyte fusion 1 Gene

Homo sapiens

Also known as OBF; IZUMO

Gene ID: 284359 | Gene type: protein coding

About IZUMO1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,740,852-48,746,909 (from NCBI)

This gene has 6 transcripts (splice variants) and 98 orthologues. Biased expression in testis (RPKM 5.7), placenta (RPKM 0.3) and 3 other tissues.

Summary

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]

IZUMO1 Products(3)

mRNA	Protein	Name
NM_001321864.1	NP_001308793.1	izumo sperm-egg fusion protein 1 isoform 2
NM_001321865.1	NP_001308794.1	izumo sperm-egg fusion protein 1 isoform 3
NM_182575.3	NP_872381.2	izumo sperm-egg fusion protein 1 isoform 1 precursor

IZUMO1 Protein Structure

IZUMO

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

izumo sperm-egg fusion protein 1

izumo sperm-egg fusion 1

Recombinant IZUMO1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77035	IZUMO1 Protein, Human (HEK293, His)	Q8IYV9-1/AAH34769.1 (C22-R292)	≥95%

Related Diseases

Diseases

Alias

Subacute Leukemia

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Enamel Erosion

Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07004	IZUMO1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS07005	IZUMO1R Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IZUMO1	RGD	RGD:1565454
Canis familiaris	IZUMO1	VGNC	VGNC:42165
Mus musculus	IZUMO1	MGD	MGI:1920706
Bos taurus	IZUMO1	VGNC	VGNC:52200
Macaca mulatta	IZUMO1	VGNC	VGNC:73670
Others	IZUMO1	NCBI

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