IZUMO1 - izumo sperm-oocyte fusion 1 Gene

Also Known as OBF; IZUMO

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 284359

About IZUMO1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,740,852-48,746,909 (from NCBI)

This gene has 6 transcripts (splice variants) and 98 orthologues. Biased expression in testis (RPKM 5.7), placenta (RPKM 0.3) and 3 other tissues.

Summary

The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]

IZUMO1 Products (3)

mRNA Protein Name
NM_001321864.1 NP_001308793.1 izumo sperm-egg fusion protein 1 isoform 2
NM_001321865.1 NP_001308794.1 izumo sperm-egg fusion protein 1 isoform 3
NM_182575.3 NP_872381.2 izumo sperm-egg fusion protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables identical protein binding IPI
IPI: Inferred from physical interaction
27309808 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27309808 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
24739963 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in fusion of sperm to egg plasma membrane involved in single fertilization IDA
IDA: Inferred from direct assay
15759005 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in membrane IDA
IDA: Inferred from direct assay
15759005 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IZUMO1 Protein Structure

IZUMO

IZUMO: Izumo sperm-egg fusion, Ig domain-associated (18 - 175)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

izumo sperm-egg fusion protein 1

  • izumo sperm-egg fusion 1

Recombinant IZUMO1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P77035 IZUMO1 Protein, Human (HEK293, His) Q8IYV9-1/AAH34769.1 (C22-R292) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Subacute Leukemia
Spermatogenic Failure 9

  • Male Infertility Due To Globozoospermia

  • SPGF9

  • Male Infertility Due To Round-Headed Spermatozoa

  • Globozoospermia, Complete

  • Globozoospermia, Total

  • Globozoospermia

  • Globozoospermia Syndrome

  • Round-Headed Sperm Syndrome

  • Globozoospermia Complete

  • Globozoospermia Total
Enamel Erosion
Chronic Purulent Otitis Media

  • Chronic Suppurative Otitis Media

  • Csom - [Chronic Suppurative Otitis Media]
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS07004 IZUMO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07005 IZUMO1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19263 Izumo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21242 Izumo1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25752 Izumo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27759 Izumo1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus IZUMO1 RGD RGD:1565454
Canis familiaris IZUMO1 VGNC VGNC:42165
Mus musculus IZUMO1 MGD MGI:1920706
Bos taurus IZUMO1 VGNC VGNC:52200
Macaca mulatta IZUMO1 VGNC VGNC:73670
Others IZUMO1 NCBI