Alox12 - arachidonate 12-lipoxygenase, 12S type Gene

Also Known as 12-LO; 12S-LOX

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 287454

About Alox12

Primary_assembly 10: 54,958,271-54,970,542 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 27 phenotypes. Biased expression in Spleen (RPKM 58.3), Uterus (RPKM 42.3) and 8 other tissues.

Summary

Predicted to enable arachidonate 12(S)-lipoxygenase activity; arachidonate 15-lipoxygenase activity; and linoleate 13S-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; positive regulation of macromolecule metabolic process; and regulation of apoptotic process. Located in cytosol and sarcolemma. Biomarker of congestive heart failure; hypertension; and obesity. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Apr 2022]

Alox12 Products (1)

mRNA	Protein	Name
NM_001105798.2	NP_001099268.2	polyunsaturated fatty acid lipoxygenase ALOX12

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	23382512	RGD
involved in cellular response to lipid	IEP IEP: Inferred from expression pattern	18680775	RGD
involved in hepoxilin biosynthetic process	IDA IDA: Inferred from direct assay	23382512	RGD
involved in lipoxygenase pathway	IDA IDA: Inferred from direct assay	23382512	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	8643560	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15105833	RGD
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	10733500	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	15105833	RGD
involved in positive regulation of endothelial tube morphogenesis	IMP IMP: Inferred from mutant phenotype	10733500	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15105833	RGD
involved in positive regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	15564577	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	15450084	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16199435	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in sarcolemma	IDA IDA: Inferred from direct assay	15107407	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox12 Protein Structure

PLAT

Lipoxygenase

0
200
400
600
663 a.a.

Protein Preferred Names	Protein Names
polyunsaturated fatty acid lipoxygenase ALOX12	12S-lipoxygenase arachidonate (12S)-lipoxygenase arachidonate (15S)-lipoxygenase arachidonate 15-lipoxygenase,15S-type linoleate 13S-lipoxygenase lipoxin synthase 12-LO platelet 12-LOX platelet-type lipoxygenase 12

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-150191	IMA-1		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2134	Mirificin		99.66%	Unkown
HY-RS00613	Alox12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113509B	15(R)-Lipoxin A4		98.3%	Unkown
HY-187182	MH-06		/	Unkown
HY-187183	IM-07	Ligand	/	Unkown
HY-RS00612	ALOX12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00614	Alox12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00615	ALOX12B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00618	Alox15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alox12	NCBI	NCBI:239