Col1a1 - collagen type I alpha 1 chain Gene

Also Known as COLIA1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29393

Summary

Predicted to enable identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent. Involved in several processes, including cellular response to growth factor stimulus; cellular response to mechanical stimulus; and cellular response to retinoic acid. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and secretory granule. Used to study cholestasis and non-alcoholic fatty liver disease. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; liver disease (multiple); pulmonary fibrosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (Collagen type I alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col1a1 Products (1)

mRNA Protein Name
NM_053304.1 NP_445756.1 collagen alpha-1(I) chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15817460 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
2016852 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
16972247 RGD
involved in cellular response to fluoride IEP
IEP: Inferred from expression pattern
21093551 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
32065356 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
22615126 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
1921334 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
19362560 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
17485223 RGD
involved in cellular response to vitamin E IEP
IEP: Inferred from expression pattern
23722449 RGD
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway IDA
IDA: Inferred from direct assay
10970885 RGD
involved in ossification IEP
IEP: Inferred from expression pattern
14595530 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
10679825 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
2456904 RGD
involved in response to fluoride IEP
IEP: Inferred from expression pattern
15552839 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
10051504 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
11918316 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
11748224 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15042712 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
20397200 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
10679825 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
21842416 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
23069578 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
2659889 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
15609627 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(I) chain

  • alpha-1 type I collagen

  • collagen, type 1, alpha 1

  • collagen, type I, alpha 1

  • procollagen type I, alpha 1

  • procollagen, type 1, alpha 1

  • type I-alpha 1 collagen

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99047 Simtuzumab Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151932 FXR agonist 3 Agonist 96.51% Unkown
HY-158231 Polyether F127 Diacrylate Activator / Unkown
HY-47888 PLN-1474 Inhibitor 99.35% Unkown
HY-Y1123 2-Aminoacetamide hydrochloride Activator 99.89% Unkown
HY-146434 TGFβ-IN-2 Inhibitor 99.37% Unkown
HY-120006A (rel)-AR234960 Agonist 98.95% Unkown
HY-W019901B Anhydrous calcium sulfate (97%) Activator 99.40% Unkown
HY-P11223 CMF9 Inhibitor 98.65% Unkown
HY-P5237 Tetrapeptide-4 Activator 99.54% Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-154979 Anti-hepatic fibrosis agent 2 / Unkown
HY-155328 GK444 Inhibitor / Unkown
HY-172258 5-HT2B antagonist-2 Inhibitor / Unkown
HY-175496 Acid Ceramidase-IN-3 Inhibitor / Unkown
HY-176737 TGF-β1/Smad-IN-1 Inhibitor / Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-179042 TGF-β/Smad-IN-3 Inhibitor / Unkown
HY-181655 Cathepsin D degrader 1 Degrader / Unkown
HY-181993 JNK3-IN-11 Inhibitor / Unkown
HY-184149 ROCK2-IN-17 Inhibitor / Unkown
HY-RS02970 COL1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16961 Col1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23404 Col1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992066 Anti-Mouse DDR2 Antibody (DAB0065) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col1a1 NCBI NCBI:1277