5-HT2B antagonist-2
5-HT2B antagonist-2 (Compound 19c) is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases.
For research use only. We do not sell to patients.
- Formula: C23H28Cl2N4O7S
- Molecular Weight:575.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
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5-HT2B Receptor |
Chemical Information
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Molecular Weight 575.46
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Formula C23H28Cl2N4O7S
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SMILES
O=C(O)[C@@H](N)CCC(N1C[C@@H](NS(=O)(C2=CC=C(OC)C(C(NC3=CC=CC=C3Cl)=O)=C2)=O)CC1)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-HT2B antagonist-2 Related Classifications
HY-172258 Related Classifications
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