Gfpt1 - glutamine fructose-6-phosphate transaminase 1 Gene

Also Known as GFA; GFAT; Gfpt; GFAT1; GFAT1m

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 297417

Summary

Enables several functions, including amino acid binding activity; glutamine-fructose-6-phosphate transaminase (isomerizing) activity; and identical protein binding activity. Involved in several processes, including fructose 6-phosphate metabolic process; glucosamine biosynthetic process; and negative regulation of glycogen biosynthetic process. Biomarker of familial hyperlipidemia and hyperinsulinism. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12 and obesity. Orthologous to human GFPT1 (glutamine--fructose-6-phosphate transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]

Gfpt1 Products (1)

mRNA Protein Name
NM_001005879.1 NP_001005879.1 glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables amino acid binding IDA
IDA: Inferred from direct assay
10898949 RGD
enables carbohydrate binding IDA
IDA: Inferred from direct assay
10898949 RGD
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IDA
IDA: Inferred from direct assay
10898949 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
10898949 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in UDP-N-acetylglucosamine metabolic process IMP
IMP: Inferred from mutant phenotype
10898949 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
10604279 RGD
involved in fructose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
10898949 RGD
involved in glucosamine biosynthetic process IDA
IDA: Inferred from direct assay
10898949 RGD
involved in negative regulation of glycogen biosynthetic process IMP
IMP: Inferred from mutant phenotype
8349040 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
7589852 RGD
involved in response to sucrose IEP
IEP: Inferred from expression pattern
16555472 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

  • D-fructose-6-phosphate amidotransferase 1

  • GFAT 1

  • glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1

  • glutamine:fructose-6-phosphate amidotransferase 1

  • hexosephosphate aminotransferase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05384 GFPT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19005 Gfpt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25494 Gfpt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gfpt1 NCBI NCBI:2673