Grik3 - glutamate ionotropic receptor kainate type subunit 3 Gene

Also Known as GluK3; GluR7; gluR-7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 298521

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Compared to Other kainate or AMPA receptors, this subunit exhibits a lower sensitivity to glutamate, and thus may play a unique role in neurotransmission in the brain. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Grik3 Products (2)

mRNA Protein Name
NM_001112716.1 NP_001106187.1 glutamate receptor ionotropic, kainate 3 isoform 1 precursor
NM_181373.3 NP_852038.2 glutamate receptor ionotropic, kainate 3 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate receptor activity IDA
IDA: Inferred from direct assay
9390526 RGD
enables glutamate-gated receptor activity IDA
IDA: Inferred from direct assay
1322826 RGD
enables glutamate-gated receptor activity IMP
IMP: Inferred from mutant phenotype
21907808 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
31311973 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
34706237 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
16420445 RGD
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
11124978 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15844209 RGD
is active in cochlear hair cell ribbon synapse IDA
IDA: Inferred from direct assay
24858010 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16360275 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
15844209 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
15844209 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
24858010 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
15844209 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor ionotropic, kainate 3

  • glutamate receptor 7

  • glutamate receptor subunit kainate subtype

  • glutamate receptor, ionotropic, kainate 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05800 GRIK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20947 Grik3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27464 Grik3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grik3 NCBI NCBI:2899