Tardbp - TAR DNA binding protein Gene

Also Known as Tdp-43

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 298648

Summary

Enables RNA binding activity. Involved in positive regulation of Insulin secretion and response to endoplasmic reticulum stress. Located in cytoplasm and nuclear lumen. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Tardbp Products (2)

mRNA Protein Name
NM_001011979.3 NP_001011979.1 TAR DNA-binding protein 43 isoform 2
NM_001399105.1 NP_001386034.1 TAR DNA-binding protein 43 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
21051541 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
21127054 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
21608013 RGD
Cellular Component GO Annotation Evidence References Source
located in interchromatin granule IDA
IDA: Inferred from direct assay
19539030 RGD
located in nuclear speck IDA
IDA: Inferred from direct assay
19539030 RGD
located in perichromatin fibrils IDA
IDA: Inferred from direct assay
19539030 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TAR DNA-binding protein 43

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS23806 Tardbp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14208 TARDBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17352 Tardbp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tardbp NCBI NCBI:23435