Pik3cg - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Gene

Also Known as Pi3k

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 298947

About Pik3cg

Primary_assembly 6: 48,766,864-48,802,043 reverse strand.mRatBN7.2:CM026979.1

This gene has 2 transcripts (splice variants), 215 orthologues, 9 paralogues and is associated with 40 phenotypes. Biased expression in Thymus (RPKM 145.7), Spleen (RPKM 18.5) and 8 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including hepatocyte apoptotic process; negative regulation of triglyceride catabolic process; and phosphatidylinositol phosphate biosynthetic process. Part of phosphatidylinositol 3-kinase complex. Used to study liver cirrhosis. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pik3cg Products (1)

mRNA Protein Name
NM_001371300.2 NP_001358229.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol-3-kinase activity IDA
IDA: Inferred from direct assay
12882977 RGD
Biological Process GO Annotation Evidence References Source
involved in hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
20675006 RGD
involved in negative regulation of triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
21435395 RGD
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
12882977 RGD
involved in positive regulation of acute inflammatory response IMP
IMP: Inferred from mutant phenotype
17526805 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
11266463 RGD
involved in secretory granule localization IMP
IMP: Inferred from mutant phenotype
19549714 RGD
Cellular Component GO Annotation Evidence References Source
part of phosphatidylinositol 3-kinase complex IDA
IDA: Inferred from direct assay
12882977 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3cg Protein Structure

PIK3CG_ABD

PIK3CG_ABD: pfam19710 (0 - 191)

PI3K_rbd

PI3K_rbd: smart00144 (202 - 311)

C2_PI3K_class_I_gamma

C2_PI3K_class_I_gamma: cd08399 (349 - 526)

PI3Ka_I

PI3Ka_I: cd00872 (548 - 724)

PI3Kc_IB_gamma

PI3Kc_IB_gamma: cd00894 (728 - 1094)

  • 0
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  • 800
  • 1000
  • 1102 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

  • phosphoinositide-3-kinase, catalytic, gamma polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70609 PIK3CG Recombinant Human Active Lipid Kinase / Unkown
HY-N0859A Schisanhenol B / Unkown
HY-RS10532 PIK3CG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10533 Pik3cg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10534 Pik3cg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3cg NCBI NCBI:5294