Adamts5 - ADAM metallopeptidase with thrombospondin type 1 motif, 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 304135

Summary

Predicted to enable extracellular matrix binding activity; heparin binding activity; and metalloendopeptidase activity. Involved in tooth eruption. Predicted to be located in extracellular space. Predicted to be active in extracellular matrix. Used to study osteoarthritis. Biomarker of degenerative disc disease; mucopolysaccharidosis VI; and osteoarthritis. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5). [provided by Alliance of Genome Resources, Apr 2022]

Adamts5 Products (1)

mRNA Protein Name
NM_198761.2 NP_942056.2 A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 5

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-137430 Aldumastat Inhibitor 99.36% Phase 2
HY-160822 AGG-523 Inhibitor 99.32% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114996 ADAMTS-5 Inhibitor Inhibitor 99.59% Unkown
HY-P10398 5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA 91.94% Unkown
HY-145061 ADAMTS-5-IN-3 Inhibitor 98.89% Unkown
HY-P5419A WAAG-3R TFA 99.75% Unkown
HY-135710 ADAMTS-5-IN-2 Inhibitor 98.73% Unkown
HY-12270S T-5224-d8 / Unkown
HY-153505 ADAMTS-4/5-IN-1 Inhibitor / Unkown
HY-180781 ADAMTS-5-IN-4 Inhibitor / Unkown
HY-P10468 5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 / Unkown
HY-RS00305 ADAMTS5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18432 Adamts5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24913 Adamts5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992336 CRB0017 Inhibitor / Unkown
HY-P992358 GSK2394002 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamts5 NCBI NCBI:11096