AOAH - acyloxyacyl hydrolase Gene

Homo sapiens

Gene ID: 313 | Gene type: protein coding

About AOAH

Cytogenetic location: 7p14.2 Genomic coordinates (GRCh38): 7:36,512,941-36,724,494 (from NCBI)

This gene has 12 transcripts (splice variants) and 122 orthologues. Biased expression in spleen (RPKM 9.9), appendix (RPKM 5.8) and 13 other tissues.

Summary

This locus encodes both the LIGHT and heavy subunits of acyloxyacyl hydrolase. The encoded Enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from Bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]

AOAH Products(3)

mRNA	Protein	Name
NM_001177506.2	NP_001170977.1	acyloxyacyl hydrolase isoform 2 preproprotein
NM_001177507.2	NP_001170978.1	acyloxyacyl hydrolase isoform 3 preproprotein
NM_001637.4	NP_001628.1	acyloxyacyl hydrolase isoform 1 preproprotein

AOAH Protein Structure

SapB_2

Lipase_GDSL

0
200
400
600
663 a.a.

Protein Preferred Names

Protein Names

acyloxyacyl hydrolase

acyloxyacyl hydrolase (neutrophil)

Related Diseases

Diseases

Alias

Chronic Frontal Sinusitis

Acute Ethmoiditis

Acute Ethmoidal Sinusitis	Acute Ethmoid Sinusitis
Ethmoidal Sinus - Acute

Xanthogranulomatous Pyelonephritis

Pyelonephritis, Xanthogranulomatous

Cervix Endometriosis

Endometriosis Of Cervix

Cervical Endometriosis

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00770	AOAH Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AOAH	VGNC	VGNC:25971
Rattus norvegicus	AOAH	RGD	RGD:1560514
Macaca mulatta	AOAH	VGNC	VGNC:69954
Mus musculus	AOAH	MGD	MGI:1350928
Canis familiaris	AOAH	VGNC	VGNC:37946
Felis catus	AOAH	VGNC	VGNC:67717