AOAH - acyloxyacyl hydrolase Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 313

About AOAH

Cytogenetic location: 7p14.2 Genomic coordinates (GRCh38): 7:36,512,941-36,724,494 (from NCBI)

This gene has 12 transcripts (splice variants) and 122 orthologues. Biased expression in spleen (RPKM 9.9), appendix (RPKM 5.8) and 13 other tissues.

Summary

This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from Bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]

AOAH Products (3)

mRNA	Protein	Name
NM_001177506.2	NP_001170977.1	acyloxyacyl hydrolase isoform 2 preproprotein
NM_001177507.2	NP_001170978.1	acyloxyacyl hydrolase isoform 3 preproprotein
NM_001637.4	NP_001628.1	acyloxyacyl hydrolase isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables acyloxyacyl hydrolase activity	IDA IDA: Inferred from direct assay	1883828	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	29343645	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	1883828	GOA
involved in lipopolysaccharide catabolic process	IDA IDA: Inferred from direct assay	1883828	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AOAH Protein Structure

SapB_2

Lipase_GDSL

0
200
400
600
663 a.a.

Protein Preferred Names	Protein Names
acyloxyacyl hydrolase	acyloxyacyl hydrolase (neutrophil)

AOAH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AOAH	P28039	DLG2	Homo sapiens	Q15700	Y2H Prey Pooling	32296183
Intra	AOAH	P28039	DLG2	Homo sapiens	Q15700	Y2H Array	32296183
Intra	AOAH	P28039	DLG2	Homo sapiens	Q15700	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chronic Frontal Sinusitis
Acute Ethmoiditis	Acute Ethmoidal Sinusitis Acute Ethmoid Sinusitis Ethmoidal Sinus - Acute
Xanthogranulomatous Pyelonephritis	Pyelonephritis, Xanthogranulomatous
Cervix Endometriosis	Endometriosis Of Cervix Cervical Endometriosis
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00770	AOAH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AOAH	VGNC	VGNC:25971
Rattus norvegicus	AOAH	RGD	RGD:1560514
Macaca mulatta	AOAH	VGNC	VGNC:69954
Mus musculus	AOAH	MGD	MGI:1350928
Canis familiaris	AOAH	VGNC	VGNC:37946
Felis catus	AOAH	VGNC	VGNC:67717
Others	AOAH	NCBI