Dgki - diacylglycerol kinase, iota Gene

Also Known as 6430604M11Rik; C130010K08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 320127

Summary

Enables GTPase inhibitor activity; diacylglycerol kinase activity; and small GTPase binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; habituation; and modulation of chemical synaptic transmission. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is expressed in cerebral cortex; cerebral cortex mantle layer; and cerebral cortex marginal layer. Orthologous to human DGKI (diacylglycerol kinase iota). [provided by Alliance of Genome Resources, Apr 2022]

Dgki Products (2)

mRNA	Protein	Name
NM_001081206.2	NP_001074675.1	diacylglycerol kinase iota isoform 1
NM_001347104.2	NP_001334033.1	diacylglycerol kinase iota isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP-dependent diacylglycerol kinase activity	IDA IDA: Inferred from direct assay	15894621	MGI
enables GTPase inhibitor activity	IDA IDA: Inferred from direct assay	15894621	MGI
enables GTPase inhibitor activity	IMP IMP: Inferred from mutant phenotype	15894621	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	15894621	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	15894621	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21119615	MGI
acts upstream of or within habituation	IMP IMP: Inferred from mutant phenotype	21119615	MGI
acts upstream of or within neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	21119615	MGI
acts upstream of or within positive regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	15894621	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	21119615	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	21119615	MGI
acts upstream of or within regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	15894621	MGI
acts upstream of or within regulation of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	21119615	MGI
acts upstream of or within regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	21119615	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	21119615	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	21119615	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15894621	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21119615	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21119615	MGI
part of guanyl-nucleotide exchange factor complex	IDA IDA: Inferred from direct assay	15894621	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15894621	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
diacylglycerol kinase iota	DAG kinase iota

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03721	DGKI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22136	Dgki Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28657	Dgki Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dgki	NCBI	NCBI:9162