TMEM119 - transmembrane protein 119 Gene

Also Known as OBIF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 338773

About TMEM119

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:108,589,851-108,598,084 (from NCBI)

This gene has 4 transcripts (splice variants) and 161 orthologues. Broad expression in gall bladder (RPKM 16.3), lymph node (RPKM 16.2) and 21 other tissues.

Summary

Involved in positive regulation of bone mineralization; positive regulation of osteoblast differentiation; and positive regulation of osteoblast proliferation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM119 Products (1)

mRNA Protein Name
NM_181724.3 NP_859075.2 transmembrane protein 119 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of bone mineralization IDA
IDA: Inferred from direct assay
20025746 GOA
involved in positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
20025746 GOA
involved in positive regulation of osteoblast proliferation IDA
IDA: Inferred from direct assay
20025746 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20025746 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane protein 119

  • osteoblast induction factor

TMEM119 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811551 TMEM119 Antibody (YA10102) WB, ICC/IF, IP, FC, ELISA Human, Mouse, Rat
HY-P84627 TMEM119 Antibody (YA4324) IHC-P, FC, ELISA Human
HY-P84627A TMEM119 Antibody (YA4324)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Malignant Iris Melanoma

  • Malignant Melanoma Of Iris

  • Melanoma Of The Iris
Sciatic Neuropathy
Lesion Of Sciatic Nerve

  • Nerve Lesion Sciatic

  • Sciatic Neuropathy
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

  • Nasu-Hakola Disease

  • Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

  • Plosl

  • Nhd

  • Presenile Dementia With Bone Cysts

  • Plo-Sl

  • PLOSL1

  • Dementia, Prefrontal, With Bone Cysts

  • Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease

  • Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

  • Hereditary Diffuse Leukoencephalopathy With Spheroids

  • Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

  • Alsp

  • Gpsc

  • Subcortical Gliosis Of Neumann

  • Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1

  • Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids

  • Hdls

  • HDLS1

  • Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia

  • Gliosis, Familial Progressive Subcortical

  • Leukoencephalopathy, Diffuse Hereditary, With Spheroids

  • Pold

  • Pigmentary Orthochromatic Leukodystrophy

  • Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

  • Familial Progressive Subcortical Gliosis

  • Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant

  • Dementia, Familial, Neumann Type

  • Adult-Onset Leukodystrophy With Neuroaxonal Spheroids

  • Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids

  • Neuroaxonal Leukodystrophy

  • Fpsg

  • Familial Dementia, Neumann Type

  • Familial Dementia Neumann Type

  • Leukoencephalopathy, Diffuse Hereditary, With Spheroid
Mononeuritis Of Lower Limb
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14655 TMEM119 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21263 Tmem119 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27782 Tmem119 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown