IFNA6 - interferon alpha 6 Gene

Also Known as IFN-alphaK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3443

About IFNA6

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:21,350,318-21,350,887 (from NCBI)

This gene has 2 transcripts (splice variants), 585 orthologues and 16 paralogues.

Summary

Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of anogenital venereal wart. [provided by Alliance of Genome Resources, Apr 2022]

IFNA6 Products (1)

mRNA Protein Name
NM_021002.2 NP_066282.1 interferon alpha-6 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNA6 Protein Structure

Interferon

Interferon: Interferon alpha/beta domain (26 - 187)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

interferon alpha-6

  • IFN-alpha-6

IFNA6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IFNA6 P05013 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
IFNA6 P05013 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
IFNA6 P05013 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNA6 Proteins

Cat. No. Product Name Accession Purity
HY-P72244 IFN-alpha 6/IFNA6 Protein, Human (His-Myc) P05013 (S21-E189) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72614 IFN-alpha 6/IFNA6 Protein, Human (HEK293, His) P05013 (S21-E189) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Multisystem Inflammatory Syndrome In Children

  • Mis-C

  • Multisystem Inflammatory Disorder In Children And Adolescents

  • Paediatric Inflammatory Multisystemic Syndrome

  • Mic
Anogenital Venereal Wart

  • Genital Warts

  • Condylomata Acuminata

  • Anogenital Warts

  • Condyloma Acuminatum

  • Anogenital Human Papilloma Virus Infectious Disease

  • Genital Wart Virus Infectious Disease

  • Venereal Wart

  • Venereal Warts

  • Verrucae Anogenitales

  • Verrucae Genitales
X-Linked Immunodeficiency 74

  • Immunodeficiency 74, Covid-19-Related, X-Linked

  • Imd74

  • Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection

  • Tlr7 Deficiency

  • X-Linked Immunodeficiency 74,Covid-19-Related
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06577 IFNA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22570 Ifna6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Others IFNA6 NCBI