IGLL1 - immunoglobulin lambda like polypeptide 1 Gene

Homo sapiens

Also known as IGO; 14.1; AGM2; IGL1; IGL5; IGLL; IGVPB; CD179b; VPREB2; IGLJ14.1

Gene ID: 3543 | Gene type: protein coding

About IGLL1

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,573,125-23,580,290 (from NCBI)

This gene has 3 transcripts (splice variants), 252 orthologues, 82 paralogues and is associated with 2 phenotypes. Biased expression in bone marrow (RPKM 17.7) and testis (RPKM 4.8).

Summary

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig LIGHT chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate LIGHT chain. This gene encodes one of the surrogate LIGHT chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or Antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

IGLL1 Products(3)

mRNA	Protein	Name
NM_001369906.1	NP_001356835.1	immunoglobulin lambda-like polypeptide 1 isoform c
NM_020070.4	NP_064455.1	immunoglobulin lambda-like polypeptide 1 isoform a precursor
NM_152855.3	NP_690594.1	immunoglobulin lambda-like polypeptide 1 isoform b precursor

IGLL1 Protein Structure

C1-set

0
100
200
213 a.a.

Protein Preferred Names

Protein Names

immunoglobulin lambda-like polypeptide 1

CD179 antigen-like family member B

Related Diseases

Diseases

Alias

Agammaglobulinemia 2, Autosomal Recessive

Agammaglobulinemia 2	AGM2
Agammaglobulinemia, Autosomal Recessive, Due To Igll1 Defect	Agammaglobulinemia Autosomal Recessive Due To Igll1 Defect
Agammaglobulinemia, Type 2, Autosomal Recessive

Lambda 5 Deficiency

Agammaglobulinemia, Non-Bruton Type

Autosomal Agammaglobulinemia

B Cell Deficiency

Immunoglobulin Heavy Chain Deficiency	B Cell Deficiencies
Immunoglobulin Heavy Chain Deletion	Humoral Immune Defect

Agammaglobulinemia

Hypogammaglobulinemia	Ighm
Mu Heavy Chain Deficiency	Mu-Heavy Chain Disease
Mu-Hcd	Mu-Chain Disease

Congenital Hypogammaglobulinemia

Congenital Hypogammaglobulinaemia

Mu Chain Disease

Mu-Chain Disease

Bird Fancier'S Lung

Bird Fancier Lung	Pigeon Breeder'S Lung
Avian Hypersensitivity Pneumonitis	Bird Breeder'S Lung
Bird-Fancier'S Lung	Bird-Fanciers' Lung
Poultry Worker'S Lung	Pigeon-Breeder Lung Disease
Pigeon Breeders Lung	Avian Protein Hypersensitivity
Bird Breeders' Disease	Bird Breeders' Lung
Bird Fanciers' Lung	Bird Fanciers' Disease
Bfl - [Bird Fancier Lung]	Fanciers' Disease
Fanciers' Lung

Heavy Chain Disease

Hcd

Amebiasis

Amoebiasis	Entamoebiasis
Chronic Intestinal Amebiasis	Amoebiasis, Unspecified
Amebic Colitis	Amoebic Enteritis
Infection Due To Entamoeba Histolytica	Amoebic Infection
Disease Due To Endamoebidae	Amoebiasis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06642	IGLL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IGLL1	MGD	MGI:96529

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