IGLL1 - immunoglobulin lambda like polypeptide 1 Gene

Also Known as IGO; 14.1; AGM2; IGL1; IGL5; IGLL; IGVPB; CD179b; VPREB2; IGLJ14.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3543

About IGLL1

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,573,125-23,580,290 (from NCBI)

This gene has 3 transcripts (splice variants), 252 orthologues, 82 paralogues and is associated with 2 phenotypes. Biased expression in bone marrow (RPKM 17.7) and testis (RPKM 4.8).

Summary

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

IGLL1 Products (3)

mRNA	Protein	Name
NM_001369906.1	NP_001356835.1	immunoglobulin lambda-like polypeptide 1 isoform c
NM_020070.4	NP_064455.1	immunoglobulin lambda-like polypeptide 1 isoform a precursor
NM_152855.3	NP_690594.1	immunoglobulin lambda-like polypeptide 1 isoform b precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19273555	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGLL1 Protein Structure

C1-set

0
100
200
213 a.a.

Protein Preferred Names	Protein Names
immunoglobulin lambda-like polypeptide 1	CD179 antigen-like family member B

IGLL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IGLL1	P15814	FAM25C	Homo sapiens	B3EWG5	Y2H Prey Pooling	32296183
Intra	IGLL1	P15814	FAM25C	Homo sapiens	B3EWG5	Y2H Array	32296183
Cross	IGLL1	P15814	q2ghu2_ehrcr	Ehrlichia chaffeensis	Q2GHU2	Anti Tag CoIP	19273555
Intra	IGLL1	P15814	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	IGLL1	P15814	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	IGLL1	P15814	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Agammaglobulinemia 2, Autosomal Recessive	Agammaglobulinemia 2 AGM2 Agammaglobulinemia, Autosomal Recessive, Due To Igll1 Defect Agammaglobulinemia Autosomal Recessive Due To Igll1 Defect Agammaglobulinemia, Type 2, Autosomal Recessive
Lambda 5 Deficiency
Agammaglobulinemia, Non-Bruton Type	Autosomal Agammaglobulinemia
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Congenital Hypogammaglobulinemia	Congenital Hypogammaglobulinaemia
Mu Chain Disease	Mu-Chain Disease
Bird Fancier'S Lung	Bird Fancier Lung Pigeon Breeder'S Lung Avian Hypersensitivity Pneumonitis Bird Breeder'S Lung Bird-Fancier'S Lung Bird-Fanciers' Lung Poultry Worker'S Lung Pigeon-Breeder Lung Disease Pigeon Breeders Lung Avian Protein Hypersensitivity Bird Breeders' Disease Bird Breeders' Lung Bird Fanciers' Lung Bird Fanciers' Disease Bfl - [Bird Fancier Lung] Fanciers' Disease Fanciers' Lung
Heavy Chain Disease	Hcd
Amebiasis	Amoebiasis Entamoebiasis Chronic Intestinal Amebiasis Amoebiasis, Unspecified Amebic Colitis Amoebic Enteritis Infection Due To Entamoeba Histolytica Amoebic Infection Disease Due To Endamoebidae Amoebiasis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06642	IGLL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22572	Igll1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29090	Igll1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IGLL1	MGD	MGI:96529