GSTK1 - glutathione S-transferase kappa 1 Gene

Also Known as GST; GST13; hGSTK1; GSTK1-1; GST13-13; GST 13-13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 373156

About GSTK1

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,263,441-143,269,115 (from NCBI)

This gene has 9 transcripts (splice variants) and 226 orthologues. Ubiquitous expression in duodenum (RPKM 118.1), small intestine (RPKM 106.3) and 25 other tissues.

Summary

This gene encodes a member of the kappa class of the glutathione transferase superfamily of Enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

GSTK1 Products (4)

mRNA Protein Name
NM_001143679.2 NP_001137151.1 glutathione S-transferase kappa 1 isoform b
NM_001143680.2 NP_001137152.1 glutathione S-transferase kappa 1 isoform c
NM_001143681.2 NP_001137153.1 glutathione S-transferase kappa 1 isoform d
NM_015917.3 NP_057001.1 glutathione S-transferase kappa 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutathione peroxidase activity IDA
IDA: Inferred from direct assay
14742434 GOA
enables glutathione transferase activity IDA
IDA: Inferred from direct assay
14742434 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19011089 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
21492153 GOA
Cellular Component GO Annotation Evidence References Source
located in peroxisome IDA
IDA: Inferred from direct assay
14742434 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTK1 Protein Structure

DSBA

DSBA: DSBA-like thioredoxin domain (7 - 210)

  • 0
  • 100
  • 200
  • 226 a.a.
Protein Preferred Names Protein Names

glutathione S-transferase kappa 1

  • GST class-kappa

GSTK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GSTK1 Q9Y2Q3 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
GSTK1 Q9Y2Q3 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
GSTK1 Q9Y2Q3 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra
GSTK1 Q9Y2Q3 CCNDBP1 Homo sapiens O95273
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GSTK1 Proteins

Cat. No. Product Name Accession Purity
HY-P75800 GSTK1 Protein, Human Q9Y2Q3-1 (G2-L226) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700381 GSTK1 Protein, Human (GST) Q9Y2Q3-1 (G2-L226) ≥ 90%, as determined by reducing SDS-PAGE.

GSTK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82443 GSTK1 Antibody (YA2188) WB, IHC-P, ICC/IF, FC, IP Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05878 GSTK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19686 Gstk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26180 Gstk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GSTK1 VGNC VGNC:29685
Rattus norvegicus GSTK1 RGD RGD:735188
Mus musculus GSTK1 MGD MGI:1923513
Macaca mulatta GSTK1 VGNC VGNC:73180
Felis catus GSTK1 VGNC VGNC:62730
Others GSTK1 NCBI