ALKAL1 - ALK and LTK ligand 1 Gene

Also Known as AUGA; AUGB; FAM150A; UNQ9433

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 389658

About ALKAL1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:52,534,037-52,565,430 (from NCBI)

This gene has 2 transcripts (splice variants) and 161 orthologues. Biased expression in gall bladder (RPKM 1.3), thyroid (RPKM 1.1) and 7 other tissues.

Summary

Enables receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of ERK5 cascade; and positive regulation of neuron projection development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

ALKAL1 Products (1)

mRNA Protein Name
NM_207413.4 NP_997296.1 ALK and LTK ligand 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
34646012 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26418745 GOA
enables receptor signaling protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
26418745 GOA
enables receptor tyrosine kinase binding IDA
IDA: Inferred from direct assay
26418745 GOA
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
34646012 GOA
Biological Process GO Annotation Evidence References Source
involved in cell surface receptor protein tyrosine kinase signaling pathway IDA
IDA: Inferred from direct assay
34646012 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
26418745 GOA
involved in positive regulation of ERK5 cascade IDA
IDA: Inferred from direct assay
26418745 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
26418745 GOA
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IDA
IDA: Inferred from direct assay
34646012 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKAL1 Protein Structure

FAM150

FAM150: FAM150 family (56 - 128)

  • 0
  • 100
  • 129 a.a.
Protein Preferred Names Protein Names

ALK and LTK ligand 1

  • AUG-beta

ALKAL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALKAL1 Q6UXT8 ALK Homo sapiens Q9UM73
Anti Tag CoIP
26418745
Intra
ALKAL1 Q6UXT8 ALK Homo sapiens Q9UM73
SPR
26418745
Intra
ALKAL1 Q6UXT8 ALK Homo sapiens Q9UM73
Anti Bait CoIP
26418745
Intra
ALKAL1 Q6UXT8 ALK Homo sapiens Q9UM73
ELISA
26418745
Intra
ALKAL1 Q6UXT8 ALK Homo sapiens Q9UM73
IF
26418745
Intra
ALKAL1 Q6UXT8 LTK Homo sapiens P29376
Anti Tag CoIP
26418745
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALKAL1 Proteins

Cat. No. Product Name Accession Purity
HY-P71584 ALKAL1 Protein, Human (His, B2M) Q6UXT8 (R28-T129) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Inflammatory Myofibroblastic Tumor

  • Inflammatory Fibrosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00601 ALKAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20137 Alkal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26640 Alkal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ALKAL1 VGNC VGNC:83979
Mus musculus ALKAL1 MGD MGI:3645495
Canis familiaris ALKAL1 VGNC VGNC:49887
Felis catus ALKAL1 VGNC VGNC:105869
Rattus norvegicus ALKAL1 RGD RGD:1583530
Others ALKAL1 NCBI