SH2D1A - SH2 domain containing 1A Gene

Also Known as LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4068

About SH2D1A

Cytogenetic location: Xq25 Genomic coordinates (GRCh38): X:124,346,563-124,373,160 (from NCBI)

This gene has 16 transcripts (splice variants), 199 orthologues, 13 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 17.0), spleen (RPKM 6.1) and 7 other tissues.

Summary

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to Other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to Infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SH2D1A Products (2)

mRNA	Protein	Name
NM_001114937.3	NP_001108409.1	SH2 domain-containing protein 1A isoform 2
NM_002351.5	NP_002342.1	SH2 domain-containing protein 1A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9774102	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	15713798	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in natural killer cell activation	IDA IDA: Inferred from direct assay	15713798	GOA
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9774102	GOA
involved in regulation of immune response	IMP IMP: Inferred from mutant phenotype	9774102	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9774102	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2D1A Protein Structure

SH2

0
100
128 a.a.

Protein Preferred Names	Protein Names
SH2 domain-containing protein 1A	Duncan disease SH2-protein

SH2D1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SH2D1A	O60880	MET	Homo sapiens	P08581	FPS	24728074
Intra	SH2D1A	O60880	CD247	Homo sapiens	P20963	Pull Down	22912825
Intra	SH2D1A	O60880	TNK2	Homo sapiens	Q07912-2	Validated Y2H	25910212
Intra	SH2D1A	O60880	TNK2	Homo sapiens	Q07912-2	Y2H Bait-Prey Pool	25910212
Intra	SH2D1A	O60880	TNK2	Homo sapiens	Q07912-2	Y2H Array	25910212
Intra	SH2D1A	O60880	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	SH2D1A	O60880	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	SH2D1A	O60880	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	SH2D1A	O60880	SLAMF6	Homo sapiens	Q96DU3	Anti Bait CoIP	16920955
Intra	SH2D1A	O60880	SLAMF6	Homo sapiens	Q96DU3	Anti Bait CoIP	24688028
Intra	SH2D1A	O60880	SLAMF6	Homo sapiens	Q96DU3	Pull Down	22912825
Intra	SH2D1A	O60880	CD244	Homo sapiens	Q9BZW8	Anti Bait CoIP	23346089
Intra	SH2D1A	O60880	CD244	Homo sapiens	Q9BZW8	Anti Bait CoIP	16920955
Intra	SH2D1A	O60880	LHX4	Homo sapiens	Q969G2	Y2H Bait-Prey Pool	25910212
Intra	SH2D1A	O60880	LHX4	Homo sapiens	Q969G2	Validated Y2H	25910212
Intra	SH2D1A	O60880	LHX4	Homo sapiens	Q969G2	Y2H Array	25910212
Intra	SH2D1A	O60880	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	25416956
Intra	SH2D1A	O60880	LHX4	Homo sapiens	Q969G2	Y2H Array	25416956
Intra	SH2D1A	O60880	SLAMF1	Homo sapiens	Q13291	FPS	10607564
Intra	SH2D1A	O60880	SLAMF1	Homo sapiens	Q13291	FPS	14674764
Intra	SH2D1A	O60880	SLAMF1	Homo sapiens	Q13291	Y2H	9774102
Intra	SH2D1A	O60880	SLAMF1	Homo sapiens	Q13291	Pull Down	10549287
Intra	SH2D1A	O60880	SLAMF1	Homo sapiens	Q13291	CoIP	11806999
Intra	SH2D1A	O60880	SLAMF1	Homo sapiens	Q13291	CoIP	11477068
Intra	SH2D1A	O60880	SLAMF1	Homo sapiens	Q13291	Y2H	11389028
Intra	SH2D1A	O60880	SLAMF1	Homo sapiens	Q13291	NMR	12225753
Intra	SH2D1A	O60880	TNK2	Homo sapiens	Q07912	Y2H Prey Pooling	25416956
Intra	SH2D1A	O60880	TNK2	Homo sapiens	Q07912	Y2H Array	25416956
Intra	SH2D1A	O60880	SRC	Homo sapiens	P12931	Y2H Pooling	32814053
Intra	SH2D1A	O60880	SRC	Homo sapiens	P12931	Validated Y2H	32814053
Intra	SH2D1A	O60880	SRC	Homo sapiens	P12931	Y2H Array	32814053
Intra	SH2D1A	O60880	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	SH2D1A	O60880	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	SH2D1A	O60880	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	SH2D1A	O60880	FOS	Homo sapiens	P01100	Y2H Pooling	32814053
Intra	SH2D1A	O60880	FOS	Homo sapiens	P01100	Validated Y2H	32814053
Intra	SH2D1A	O60880	FOS	Homo sapiens	P01100	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SH2D1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71038	SH2D1A Protein, Human (His)	O60880 (M1-P128)	≥ 95%, as determined by reducing SDS-PAGE.

SH2D1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82205	SH2D1A Antibody (YA1950)	WB	Human, Mouse, Rat
HY-P82205A	SH2D1A Antibody (YA1950)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp X-Linked Lymphoproliferative Disease XLP1 Lyp Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Dysgammaglobulinemia
Hemophagocytic Lymphohistiocytosis	Lymphohistiocytosis, Hemophagocytic Haemophagocytic Syndrome Lymphohistiocytosis Hemophagocytic Hemophagocytic Syndrome Familial Hemophagocytic Lymphocytosis Histiocytoses Of Mononuclear Phagocytes Haemophagocytic Lymphohistiocytosis Nos
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Selective Immunoglobulin Deficiency Disease
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Lymphoproliferative Syndrome, X-Linked, 2	XLP2 Xiap Deficiency X-Linked Lymphoproliferative Syndrome 2 X-Linked Lymphoproliferative Disease Due To Xiap Deficiency Xiap-Related Lymphoproliferative Disease, X-Linked X-Linked Lymphoproliferative Syndrome Type 2 Xiap Deficiency Syndrome
Autoinflammatory Syndrome
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Hemophagocytic Lymphohistiocytosis, Familial, 1	Familial Hemophagocytic Lymphohistiocytosis Fhl Familial Erythrophagocytic Lymphohistiocytosis Hemophagocytic Syndrome FHL1 Hplh1 Hlh1 Fel Familial Hemophagocytic Lymphohistiocytosis 1 Primary Hemophagocytic Lymphohistiocytosis Familial Hlh Hlh Familial Hemophagocytic Lymphocytosis Hemophagocytic Lymphohistiocytosis, Familial Reticulosis, Familial Histiocytic Hemophagocytic Reticulosis, Familial Erythrophagocytic Lymphohistiocytosis, Familial Familial Histiocytic Reticulosis Familial Hemophagocytic Histiocytosis Familial Hemophagocytic Reticulosis Fhlh Hplh Primary Hemophagocytic Hymphohistiocytosis Genetic Hemophagocytic Lymphohistiocytosis Hemophagocytic Lymphohistiocytosis Familial Hemophagocytic Lymphohistiocytosis Type 1
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Limbic Encephalitis
Meningoencephalitis	Acquired Toxoplasmal Meningoencephalitis Meningoencephalitis Due To Acquired Toxoplasmosis Meningoencephalitis Due To Toxoplasmosis Toxoplasma Meningoencephalitis
Ras-Associated Autoimmune Leukoproliferative Disorder	RALD Autoimmune Lymphoproliferative Syndrome Type 4 Alps4 Autoimmune Lymphoproliferative Syndrome, Type Iv Ras-Associated Autoimmune Leukoproliferative Disease Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic Alps Type 4 Alps Type Iv Autoimmune Lymphoproliferative Syndrome Type Iv Autoimmune Lymphoproliferative Syndrome 4
Familial Hemophagocytic Lymphohistiocytosis 5	Fhl5 Hlh5 Hplh5 Lymphohistiocytosis, Hemophagocytic, Familial, Type 5
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Cd40 Ligand Deficiency	X-Linked Hyper Igm Syndrome Hyperimmunoglobulin M Syndrome Higm1 Hyper-Igm Syndrome Type 1 X-Linked Hyper-Igm Syndrome Xhigm Higmx-1 X-Linked Hyper-Igm Immunodeficiency Hyper-Igm Syndrome 1 Immunodeficiency With Hyper-Igm, Type 1 Hyper-Igm Syndrome Due To Cd40 Ligand Deficiency Hyper-Igm Syndrome Due To Cd40l Deficiency Hyper-Igm Immunodeficiency Syndrome Hyper-Igm Immunodeficiency Syndrome, Type 1
Pancytopenia
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	XMEN X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia Cid Due To Magt1 Deficiency Combined Immunodeficiency Due To Magt1 Deficiency X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia
Lymphoproliferative Syndrome 2	Cd27 Deficiency LPFS2 Combined Immunodeficiency Due To Cd27 Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Cd3zeta Deficiency
Vasculitis	Angiitis Autoimmune Vasculitis Systemic Vasculitis Vasculitis, Autoimmune
Hemophagocytic Lymphohistiocytosis, Familial, 2	Familial Hemophagocytic Lymphohistiocytosis 2 FHL2 Hplh2 Hlh2 Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To Lymphohistiocytosis, Hemophagocytic, Familial, Type 2
Immunodeficiency 14	Activated Pi3k-Delta Syndrome Apds Pasli Disease Imd14 Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation P110 Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency
Hemophagocytic Lymphohistiocytosis, Familial, 3	Familial Hemophagocytic Lymphohistiocytosis 3 FHL3 Hplh3 Hlh3 Lymphohistiocytosis, Hemophagocytic, Familial, Type 3
Griscelli Syndrome	Chediak-Higashi-Like Syndrome Griscelli-Prunieras Syndrome Partial Albinism-Immunodeficiency Syndrome Griscelli Disease Gs Hypopigmentation Immunodeficiency Disease Partial Albinism With Immunodeficiency Immunodeficiency Syndrome With Hypopigmentation Hypopigmentation-Immunodeficiency Disease
Griscelli Syndrome, Type 2	Griscelli Syndrome Type 2 GS2 Griscelli Syndrome With Hemophagocytic Syndrome Partial Albinism And Immunodeficiency Syndrome Paid Syndrome Hypopigmentation-Immunodeficiency With Or Without Neurologic Impairment Syndrome Griscelli-Prunieras Syndrome Type 2 Griscelli-Pruniéras Syndrome Type 2 Griscelli Syndrome 2
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Immunodeficiency 7	Tcr-Alpha-Beta-Positive T-Cell Deficiency IMD7 T-Cell Receptor-Alpha/Beta Deficiency Immunodeficiency 7, Tcr-Alpha/Beta Deficient Tcr-Alpha/Beta Deficiency Tcr-Alpha-Beta+ T-Cell Deficiency T-Cell Receptor Alpha/Beta Deficiency
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Chediak-Higashi Syndrome	CHS Chédiak-Higashi Syndrome Chediak - Steinbrinck Anomaly Chediak Higashi Syndrome Chediak-Steinbrinck-Higashi Syndrome Oculocutaneous Albinism With Leukocyte Defect Chediak-Higashi Disease Chediak-Higashi-Steinbrink Syndrome
Systemic Epstein-Barr Virus Positive T-Cell Lymphoma Of Childhood	Ebv-Positive T-Cell Lymphoproliferative Disorder Of Childhood Systemic Epstein-Barr Virus-Positive T-Cell Lymphoma Of Childhood Systemic Ebv-Positive T-Cell Lymphoma Of Childhood Systemic Ebv+ T-Cell Lymphoma Of Childhood
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Acute Hemorrhagic Encephalitis
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12821	SH2D1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21930	Sh2d1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28446	Sh2d1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SH2D1A	MGD	MGI:1328352
Bos taurus	SH2D1A	VGNC	VGNC:56954
Canis familiaris	SH2D1A	VGNC	VGNC:54598
Rattus norvegicus	SH2D1A	RGD	RGD:1562408
Felis catus	SH2D1A	VGNC	VGNC:65091
Macaca mulatta	SH2D1A	VGNC	VGNC:97828
Others	SH2D1A	NCBI