MYO9B - myosin IXB Gene

Also Known as MYR5; CELIAC4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4650

About MYO9B

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,075,777-17,215,255 (from NCBI)

This gene has 20 transcripts (splice variants), 282 orthologues, 43 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 30.6), bone marrow (RPKM 21.4) and 24 other tissues.

Summary

This gene encodes a member of the Myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind Calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

MYO9B Products (2)

mRNA Protein Name
NM_001130065.2 NP_001123537.1 unconventional myosin-IXb isoform 2
NM_004145.4 NP_004136.2 unconventional myosin-IXb isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IDA
IDA: Inferred from direct assay
16338935 GOA
enables ATP binding IDA
IDA: Inferred from direct assay
16338935 GOA
enables GTPase activator activity IDA
IDA: Inferred from direct assay
9490638 GOA
enables Roundabout binding IPI
IPI: Inferred from physical interaction
26529257 GOA
enables actin binding IDA
IDA: Inferred from direct assay
9490638 GOA
enables calmodulin binding IDA
IDA: Inferred from direct assay
9490638 GOA
enables microfilament motor activity IDA
IDA: Inferred from direct assay
9490638 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15644318 GOA
NOT enables protein homodimerization activity IDA
IDA: Inferred from direct assay
11901422 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
26529257 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in ARF protein signal transduction IDA
IDA: Inferred from direct assay
15644318 GOA
involved in Roundabout signaling pathway IDA
IDA: Inferred from direct assay
26529257 GOA
involved in actin filament-based movement IDA
IDA: Inferred from direct assay
9490638 GOA
involved in regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
26529257 GOA
Cellular Component GO Annotation Evidence References Source
located in actin filament IDA
IDA: Inferred from direct assay
8907710 GOA
located in cell cortex IDA
IDA: Inferred from direct assay
8907710 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
8907710 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
8907710 GOA
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
30123108 GOA
is active in postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
30123108 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO9B Protein Structure

RA

RA: Ras association (RalGDS/AF-6) domain (17 - 113)

Myosin_head

Myosin_head: Myosin head (motor domain) (149 - 941)

IQ

IQ: IQ calmodulin-binding motif (958 - 976)

IQ

IQ: IQ calmodulin-binding motif (981 - 999)

IQ

IQ: IQ calmodulin-binding motif (1002 - 1022)

IQ

IQ: IQ calmodulin-binding motif (1026 - 1044)

RhoGAP

RhoGAP: RhoGAP domain (1713 - 1860)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2157 a.a.
Protein Preferred Names Protein Names

unconventional myosin-IXb

  • myosin-IXb

Related Diseases

Diseases Alias
Celiac Disease 4

  • Celiac Disease, Susceptibility To, 4

  • CELIAC4

  • Gluten-Sensitive Enteropathy 4

  • Gluten-Sensitive Enteropathy, Susceptibility To, 4

  • Celiac Disease, Susceptibility To, Type 4
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Dermatitis Herpetiformis

  • Duhring'S Disease

  • Duhring-Brocq Disease

  • Dermatosis Herpetiformis

  • Brocq-Duhring Disease

  • Dh

  • Duhring Brocq Disease

  • Dh - [Dermatitis Herpetiformis]
Ulcerative Colitis

  • Colitis Gravis

  • Left Sided Ulcerative Colitis

  • Left-Sided Ulcerative Colitis

  • Idiopathic Proctocolitis

  • Inflammatory Bowel Disease, Ulcerative Colitis Type

  • Uc

  • Colitis Ulcerative

  • Colitis, Ulcerative

  • Chronic Left-Sided Ulcerative Colitis

  • Uc - [Ulcerative Colitis]

  • Chronic Ulcerative Enteritis

  • Mucosal Proctocolitis

  • Ulcerative Mucosal Proctocolitis

  • Left Hemicolitis
Inflammatory Bowel Disease 6

  • IBD6
Colitis
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Jejunoileitis
Inflammatory Bowel Disease 5

  • IBD5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08953 MYO9B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22665 Myo9b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29179 Myo9b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MYO9B RGD RGD:3146
Canis familiaris MYO9B VGNC VGNC:43575
Felis catus MYO9B VGNC VGNC:68402
Bos taurus MYO9B VGNC VGNC:31832
Mus musculus MYO9B MGD MGI:106624
Others MYO9B NCBI