NOX3 - NADPH oxidase 3 Gene

Also Known as MOX-2; GP91-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50508

About NOX3

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:155,395,368-155,455,839 (from NCBI)

This gene has 1 transcript (splice variant), 136 orthologues and 6 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the NOX family of NADPH oxidases. These Enzymes have the capacity to generate superoxide and other Reactive Oxygen Species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]

NOX3 Products (1)

mRNA Protein Name
NM_015718.3 NP_056533.1 NADPH oxidase 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
15824103 GOA
enables superoxide-generating NAD(P)H oxidase activity IDA
IDA: Inferred from direct assay
15181005 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOX3 Protein Structure

Ferric_reduct

Ferric_reduct: Ferric reductase like transmembrane component (58 - 217)

FAD_binding_8

FAD_binding_8: FAD-binding domain (293 - 391)

NAD_binding_6

NAD_binding_6: Ferric reductase NAD binding domain (401 - 548)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 568 a.a.
Protein Preferred Names Protein Names

NADPH oxidase 3

  • NADPH oxidase catalytic subunit-like 3

Related Diseases

Diseases Alias
Drug-Induced Hearing Loss

  • Drug Induced Hearing Loss
Phagocyte Bactericidal Dysfunction

  • Phagocytic Dysfunction
Granulomatous Disease, Chronic, X-Linked

  • CGDX

  • Chronic Granulomatous Disease, X-Linked

  • X-Linked Chronic Granulomatous Disease

  • Cgd

  • Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked

  • Cdgx

  • X-Linked Chronic Cytochrome B-Negative Granulomatous Disease

  • Chronic Granulomatous Disease Cytochrome B-Negative X-Linked

  • Chronic Granulomatous Disease Cytochrome B-Positive X-Linked

  • Granulomatous Disease, Chronic, X-Linked, Variant
Chronic Granulomatous Disease

  • Cgd

  • Granulomatous Disease, Chronic

  • Autosomal Recessive Chronic Granulomatous Disease

  • X-Linked Chronic Granulomatous Disease

  • Bridges-Good Syndrome

  • Congenital Dysphagocytosis

  • Quie Syndrome

  • Chronic Septic Granulomatosis

  • Chronic Granulomatous Disorder

  • Granulomatous Disease Chronic

  • Granulomatous Disease, Chronic, X-Linked
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-120801A APX-115 free base Inhibitor 99.54% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-120801 APX-115 Inhibitor 99.90% Unkown
HY-RS09460 NOX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-148936 GLX481372 Inhibitor / Unkown
HY-RS20784 Nox3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27298 Nox3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NOX3 VGNC VGNC:43904
Felis catus NOX3 VGNC VGNC:68523
Mus musculus NOX3 MGD MGI:2681162
Rattus norvegicus NOX3 RGD RGD:1303190
Macaca mulatta NOX3 VGNC VGNC:75375
Bos taurus NOX3 VGNC VGNC:32183
Others NOX3 NCBI