2. Gene
  3. SNTG1 - syntrophin gamma 1 Gene

SNTG1 - syntrophin gamma 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SYN4; G1SYN

Gene ID: 54212 | Gene type: protein coding

About SNTG1

Cytogenetic location: 8q11.21 Genomic coordinates (GRCh38): 8:49,909,796-50,796,692 (from NCBI)

This gene has 24 transcripts (splice variants), 209 orthologues and 4 paralogues. Biased expression in brain (RPKM 1.6), spleen (RPKM 0.7) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

SNTG1 Products(8)

mRNA Protein Name
NM_001287813.3 NP_001274742.1 gamma-1-syntrophin isoform 1
NM_001287814.3 NP_001274743.1 gamma-1-syntrophin isoform 2
NM_001321773.2 NP_001308702.1 gamma-1-syntrophin isoform 1
NM_001321775.2 NP_001308704.1 gamma-1-syntrophin isoform 3
NM_001321776.2 NP_001308705.1 gamma-1-syntrophin isoform 3
NM_001321777.2 NP_001308706.1 gamma-1-syntrophin isoform 3
NM_001321778.2 NP_001308707.1 gamma-1-syntrophin isoform 3
NM_018967.5 NP_061840.1 gamma-1-syntrophin isoform 1

SNTG1 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (58 - 136)

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  • 517 a.a.
Protein Preferred Names Protein Names

gamma-1-syntrophin

gamma1-syntrophin

Recombinant SNTG1 Proteins

Cat. No. Product Name Accession Purity
HY-P71635 SNTG1 Protein, Human (Myc, His) Q9NSN8 (1M-517T) ≥95%

Related Diseases

Diseases Alias
Idiopathic Scoliosis

Scoliosis Idiopathic
Scoliosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13515 SNTG1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SNTG1 VGNC VGNC:35085
Rattus norvegicus SNTG1 RGD RGD:1560290
Felis catus SNTG1 VGNC VGNC:81675
Mus musculus SNTG1 MGD MGI:1918346
Canis familiaris SNTG1 VGNC VGNC:46615
Macaca mulatta SNTG1 VGNC VGNC:77693
Others SNTG1 NCBI