UGT1A7 - UDP glucuronosyltransferase family 1 member A7 Gene

Also Known as GNT1; UGT1; UDPGT; UGT1A; UGT1G; UGT-1A; UGT-1G; UGT1.1; UGT1.7; UGT1A1; UGT1-01; UGT1-07; hUG-BR1; UDPGT 1-7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54577

About UGT1A7

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,681,901-233,773,300 (from NCBI)

This gene has 2 transcripts (splice variants), 1221 orthologues and 21 paralogues.

Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as Steroids, bilirubin, Hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with Phenols. [provided by RefSeq, Jul 2008]

UGT1A7 Products (1)

mRNA	Protein	Name
NM_019077.3	NP_061950.2	UDP-glucuronosyltransferase 1A7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	17179145	GOA
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	19996319	GOA
enables enzyme inhibitor activity	IGI IGI: Inferred from genetic interaction	20610558	GOA
enables glucuronosyltransferase activity	IDA IDA: Inferred from direct assay	17179145	GOA
NOT enables glucuronosyltransferase activity	IGI IGI: Inferred from genetic interaction	20610558	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	20610558	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17179145	GOA
enables protein kinase C binding	IDA IDA: Inferred from direct assay	18556656	GOA
enables retinoic acid binding	IDA IDA: Inferred from direct assay	20308471	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular glucuronidation	IDA IDA: Inferred from direct assay	17179145	GOA
involved in estrogen metabolic process	IDA IDA: Inferred from direct assay	18719240	GOA
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA
involved in flavonoid glucuronidation	IDA IDA: Inferred from direct assay	20056724	GOA
involved in negative regulation of cellular glucuronidation	IDA IDA: Inferred from direct assay	20610558	GOA
involved in negative regulation of fatty acid metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA
involved in toxin catabolic process	IDA IDA: Inferred from direct assay	18556656	GOA
involved in xenobiotic glucuronidation	IDA IDA: Inferred from direct assay	20056724	GOA
NOT involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17179145	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UGT1A7 Protein Structure

UDPGT

0
100
200
300
400
500
530 a.a.

Protein Preferred Names	Protein Names
UDP-glucuronosyltransferase 1A7	Bilirubin-specific UDPGT isozyme 1

Related Diseases

Diseases	Alias
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Gilbert Syndrome	Gilbert Disease Gilbert'S Disease Gilbert'S Syndrome Cholemia, Familial Familial Nonhemolytic Jaundice Meulengracht Syndrome Gilbert Syndrome, Susceptibility To Hyperbilirubinemia, Gilbert Type Hblrg Hyperbilirubinemia, Arias Type Hyperbilirubinemia I Constitutional Hyperbilirubinemia Gilbert-Meulengracht Syndrome Hereditary Nonhemolytic Jaundice Hyperbilirubinemia Arias Type Hyperbilirubinemia Type 1 Constitutional Liver Dysfunction Gilbert-Lereboullet Syndrome Hyperbilirubinemia 1 Unconjugated Benign Bilirubinemia GILBS Gilberts Syndrome Familial Nonhaemolytic Jaundice Constitutional Hyperbilirubinaemia Hereditary Nonhaemolytic Bilirubinaemia Familial Nonhaemolytic Bilirubinaemia Idiopathic Hyperbilirubinaemia Icterus Intermittens Juvenilis Chronic Intermittent Juvenile Jaundice Low-Grade Chronic Hyperbilirubinaemia Syndrome Benign Unconjugated Bilirubinaemia Syndrome Hereditary Nonhaemolytic Jaundice Idiopathic Unconjugated Hyperbilirubinaemia Gilbert--Lereboullet Syndrome Constitutional Hepatic Dysfunction Meulengracht Icterus Cholaemia Familiaris Simplex Familial Cholaemia Congenital Familial Cholaemia Physiologic Cholaemia Hyperbilirubinaemia Type 1 Gilbert Cholaemia
Bilirubin, Serum Level Of, Quantitative Trait Locus 1	Bilirubin, Serum Level Of, Qtl1 BILIQTL1 Bilirubin, Serum Level Of, Quantitative Trait Locus, Type 1
Hyperbilirubinemia, Transient Familial Neonatal	Lucey-Driscoll Syndrome Transient Familial Neonatal Hyperbilirubinemia HBLRTFN Hyperbilirubinemia, Familial Transient Neonatal Hyperbilirubinemia Transient Familial Neonatal Transient Familial Hyperbilirubinemia
Crigler-Najjar Syndrome, Type Ii	Crigler-Najjar Syndrome Type 2 Hyperbilirubinemia, Crigler-Najjar Type Ii Hblrcn2 Arias Syndrome Crigler Najjar Syndrome Type 2 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 2 Bilirubin-Ugt Deficiency Type 2 Crigler-Najjar Syndrome 2 CN2 Cn-Ii Crigler-Najjar Syndrome Type Ii Crigler Najjar Syndrome, Type 2
Crigler-Najjar Syndrome, Type I	Crigler-Najjar Syndrome Crigler-Najjar Syndrome Type 1 Bilirubin Udp Glucuronyl Transferase Deficiency Crigler Najjar Syndrome Crigler Najjar Syndrome, Type 1 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Bilirubin-Ugt Deficiency Hyperbilirubinemia, Crigler-Najjar Type I Hblrcn1 Familial Nonhemolytic Unconjugated Hyperbilirubinemia Hereditary Unconjugated Hyperbilirubinemia Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1 Bilirubin-Ugt Deficiency Type 1 Crigler-Najjar Syndrome 1 CN1 Cn-I Crigler-Najjar Syndrome Type I Hereditary Unconjugated Hyperbilirubinaemia Ugt Deficiency Bilirubin Glucuronosyltransferase Deficiency Crigler-Najjar Disease Or Syndrome Deficiency Of Glucuronosyltransferase Glucuronyl Transferase Deficiency Glucuronyltransferase Deficiency Udp Glucuronyl Transferase Deficiency Cns - [Crigler-Najjar Syndrome] Congenital Familial Nonhemolytic Jaundice
Pancreas Disease	Abnormality Of The Pancreas Pancreatic Diseases
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130046	16-Epiestriol	Inhibitor	99.04%	Unkown
HY-D3180	CDr20		/	Unkown
HY-E72109	Human UGT1A7		/	Unkown
HY-RS15431	UGT1A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N3989	Haplopine		99.49%	Unkown