UGT1A3 - UDP glucuronosyltransferase family 1 member A3 Gene

Also Known as UDPGT; UGT1C; UGT-1C; UGT1.3; UGT1-03; UGT1A3S; UDPGT 1-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54659

About UGT1A3

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,729,042-233,773,300 (from NCBI)

This gene has 1 transcript (splice variant), 1237 orthologues and 21 paralogues.

Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as Steroids, bilirubin, Hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008]

UGT1A3 Products (1)

mRNA Protein Name
NM_019093.4 NP_061966.1 UDP-glucuronosyltransferase 1A3 precursor

UGT1A3 Protein Structure

UDPGT

UDPGT: UDP-glucoronosyl and UDP-glucosyl transferase (29 - 525)

  • 0
  • 100
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  • 500
  • 534 a.a.
Protein Preferred Names Protein Names

UDP-glucuronosyltransferase 1A3

  • UDP glucuronosyltransferase 1 family, polypeptide A3

Related Diseases

Diseases Alias
Bilirubin, Serum Level Of, Quantitative Trait Locus 1

  • Bilirubin, Serum Level Of, Qtl1

  • BILIQTL1

  • Bilirubin, Serum Level Of, Quantitative Trait Locus, Type 1
Hyperbilirubinemia, Transient Familial Neonatal

  • Lucey-Driscoll Syndrome

  • Transient Familial Neonatal Hyperbilirubinemia

  • HBLRTFN

  • Hyperbilirubinemia, Familial Transient Neonatal

  • Hyperbilirubinemia Transient Familial Neonatal

  • Transient Familial Hyperbilirubinemia
Crigler-Najjar Syndrome, Type Ii

  • Crigler-Najjar Syndrome Type 2

  • Hyperbilirubinemia, Crigler-Najjar Type Ii

  • Hblrcn2

  • Arias Syndrome

  • Crigler Najjar Syndrome Type 2

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 2

  • Bilirubin-Ugt Deficiency Type 2

  • Crigler-Najjar Syndrome 2

  • CN2

  • Cn-Ii

  • Crigler-Najjar Syndrome Type Ii

  • Crigler Najjar Syndrome, Type 2
Bilirubin Metabolic Disorder

  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia
Gilbert Syndrome

  • Gilbert Disease

  • Gilbert'S Disease

  • Gilbert'S Syndrome

  • Cholemia, Familial

  • Familial Nonhemolytic Jaundice

  • Meulengracht Syndrome

  • Gilbert Syndrome, Susceptibility To

  • Hyperbilirubinemia, Gilbert Type

  • Hblrg

  • Hyperbilirubinemia, Arias Type

  • Hyperbilirubinemia I

  • Constitutional Hyperbilirubinemia

  • Gilbert-Meulengracht Syndrome

  • Hereditary Nonhemolytic Jaundice

  • Hyperbilirubinemia Arias Type

  • Hyperbilirubinemia Type 1

  • Constitutional Liver Dysfunction

  • Gilbert-Lereboullet Syndrome

  • Hyperbilirubinemia 1

  • Unconjugated Benign Bilirubinemia

  • GILBS

  • Gilberts Syndrome

  • Familial Nonhaemolytic Jaundice

  • Constitutional Hyperbilirubinaemia

  • Hereditary Nonhaemolytic Bilirubinaemia

  • Familial Nonhaemolytic Bilirubinaemia

  • Idiopathic Hyperbilirubinaemia

  • Icterus Intermittens Juvenilis

  • Chronic Intermittent Juvenile Jaundice

  • Low-Grade Chronic Hyperbilirubinaemia Syndrome

  • Benign Unconjugated Bilirubinaemia Syndrome

  • Hereditary Nonhaemolytic Jaundice

  • Idiopathic Unconjugated Hyperbilirubinaemia

  • Gilbert--Lereboullet Syndrome

  • Constitutional Hepatic Dysfunction

  • Meulengracht Icterus

  • Cholaemia Familiaris Simplex

  • Familial Cholaemia

  • Congenital Familial Cholaemia

  • Physiologic Cholaemia

  • Hyperbilirubinaemia Type 1

  • Gilbert Cholaemia
Crigler-Najjar Syndrome, Type I

  • Crigler-Najjar Syndrome

  • Crigler-Najjar Syndrome Type 1

  • Bilirubin Udp Glucuronyl Transferase Deficiency

  • Crigler Najjar Syndrome

  • Crigler Najjar Syndrome, Type 1

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency

  • Bilirubin-Ugt Deficiency

  • Hyperbilirubinemia, Crigler-Najjar Type I

  • Hblrcn1

  • Familial Nonhemolytic Unconjugated Hyperbilirubinemia

  • Hereditary Unconjugated Hyperbilirubinemia

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1

  • Bilirubin-Ugt Deficiency Type 1

  • Crigler-Najjar Syndrome 1

  • CN1

  • Cn-I

  • Crigler-Najjar Syndrome Type I

  • Hereditary Unconjugated Hyperbilirubinaemia

  • Ugt Deficiency

  • Bilirubin Glucuronosyltransferase Deficiency

  • Crigler-Najjar Disease Or Syndrome

  • Deficiency Of Glucuronosyltransferase

  • Glucuronyl Transferase Deficiency

  • Glucuronyltransferase Deficiency

  • Udp Glucuronyl Transferase Deficiency

  • Cns - [Crigler-Najjar Syndrome]

  • Congenital Familial Nonhemolytic Jaundice
Acetaminophen Metabolism
Kernicterus

  • Bilirubin Encephalopathy

  • Hyperbilirubinemic Encephalopathy

  • Kernicterus Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-124364 RO6889678 / Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-106181 Rivoglitazone Agonist 98.59% Unkown
HY-130046 16-Epiestriol Inhibitor 99.04% Unkown
HY-N4267 Yangambin 98.27% Unkown
HY-E72106 Human UGT1A3 Control / Unkown
HY-E72107 Human UGT1A4 / Unkown
HY-RS15428 UGT1A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15430 UGT1A6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26323 Ugt1a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UGT1A3 MGD MGI:3576049
Rattus norvegicus UGT1A3 RGD RGD:1549741