Human UGT1A4
Human UGT1A4 is a UDP-glucuronosyltransferase. Human UGT1A4 is the major enzyme catalyzing the glucuronidation of 25-hydroxyvitamin D3 (HY-32351) in the liver, and maintains vitamin D homeostasis by clearing 25-hydroxyvitamin D3. Human UGT1A4 regulates the substrate-dependent enzymatic activities of UGT1A1 and UGT1A6, while its own activity is also subject to substrate-dependent regulation by co-expressed UGT1A1 and UGT1A6.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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UGT1A1 |
UGT1A4 |
UGT1A6 |
Chemical Information
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SMILES
[Human UGT1A4]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang Z, et al. Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability. Endocrinology. 2014 Jun;155(6):2052-63. [Content Brief]
[2]. Fujiwara R, et al. Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities. Drug metabolism and disposition: the biological fate of chemicals. 2007 Oct;35(10):1781-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Human UGT1A4 Related Classifications
HY-E72107 Related Classifications
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