BANK1 - B cell scaffold protein with ankyrin repeats 1 Gene

Also Known as BANK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55024

About BANK1

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:101,790,730-102,074,812 (from NCBI)

This gene has 8 transcripts (splice variants), 175 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in lymph node (RPKM 39.0), spleen (RPKM 27.4) and 8 other tissues.

Summary

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

BANK1 Products (3)

mRNA	Protein	Name
NM_001083907.3	NP_001077376.3	B-cell scaffold protein with ankyrin repeats isoform 2
NM_001127507.3	NP_001120979.3	B-cell scaffold protein with ankyrin repeats isoform 3
NM_017935.5	NP_060405.5	B-cell scaffold protein with ankyrin repeats isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phospholipase binding	IPI IPI: Inferred from physical interaction	23555801	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	23555801	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11782428	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	11782428	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	23555801	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11782428	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell activation	IDA IDA: Inferred from direct assay	11782428	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	11782428	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	23555801	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BANK1 Protein Structure

DBB

0
200
400
600
785 a.a.

Protein Preferred Names	Protein Names
B-cell scaffold protein with ankyrin repeats

BANK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BANK1	Q8NDB2	BLK	Homo sapiens	P51451	Anti Bait CoIP	21978998
Intra	BANK1	Q8NDB2	BLK	Homo sapiens	P51451	Confocal	21978998
Intra	BANK1	Q8NDB2	BLK	Homo sapiens	P51451	Anti Tag CoIP	21978998
Intra	BANK1	Q8NDB2	LYN	Homo sapiens	P07948	Anti Bait CoIP	11782428
Intra	BANK1	Q8NDB2	LYN	Homo sapiens	P07948	Anti Tag CoIP	11782428
Intra	BANK1	Q8NDB2	LYN	Homo sapiens	P07948	Pull Down	11782428

Cross: Cross-species interaction Intra: Intraspecies interaction

BANK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81434	BANK1 Antibody (YA1179)	IHC-P	Human
HY-P81434A	BANK1 Antibody (YA1179)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Facial Hemiatrophy	Parry-Romberg Syndrome
Diffuse Scleroderma	Diffuse Systemic Sclerosis Systemic Sclerosis, Diffuse Scleroderma, Diffuse Systemic Scleroderma Progressive System Sclerosis
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01362	BANK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21495	Bank1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28013	Bank1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W725041	Methiozolin		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BANK1	VGNC	VGNC:38377
Mus musculus	BANK1	MGD	MGI:2442120
Bos taurus	BANK1	VGNC	VGNC:106648
Macaca mulatta	BANK1	VGNC	VGNC:70090
Rattus norvegicus	BANK1	RGD	RGD:1564639
Felis catus	BANK1	VGNC	VGNC:78456
Others	BANK1	NCBI