BANK1 - B cell scaffold protein with ankyrin repeats 1 Gene

Homo sapiens

Also known as BANK

Gene ID: 55024 | Gene type: protein coding

About BANK1

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:101,790,730-102,074,812 (from NCBI)

This gene has 8 transcripts (splice variants), 175 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in lymph node (RPKM 39.0), spleen (RPKM 27.4) and 8 other tissues.

Summary

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

BANK1 Products(3)

mRNA	Protein	Name
NM_001083907.3	NP_001077376.3	B-cell scaffold protein with ankyrin repeats isoform 2
NM_001127507.3	NP_001120979.3	B-cell scaffold protein with ankyrin repeats isoform 3
NM_017935.5	NP_060405.5	B-cell scaffold protein with ankyrin repeats isoform 1

BANK1 Protein Structure

DBB

0
200
400
600
785 a.a.

Protein Preferred Names

Protein Names

B-cell scaffold protein with ankyrin repeats

Related Diseases

Diseases

Alias

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Facial Hemiatrophy

Parry-Romberg Syndrome

Diffuse Scleroderma

Diffuse Systemic Sclerosis	Systemic Sclerosis, Diffuse
Scleroderma, Diffuse	Systemic Scleroderma
Progressive System Sclerosis

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01362	BANK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BANK1	VGNC	VGNC:38377
Mus musculus	BANK1	MGD	MGI:2442120
Bos taurus	BANK1	VGNC	VGNC:106648
Macaca mulatta	BANK1	VGNC	VGNC:70090
Rattus norvegicus	BANK1	RGD	RGD:1564639
Felis catus	BANK1	VGNC	VGNC:78456

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