Nptn - neuroplastin Gene

Also Known as SDR-1; Sdfr1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 56064

Summary

Enables cell adhesion molecule binding activity; transmembrane transporter binding activity; and type 1 Fibroblast Growth Factor receptor binding activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of signal transduction; and regulation of synaptic plasticity. Located in several cellular components, including inhibitory synapse; postsynaptic density; and presynaptic membrane. Is active in several cellular components, including GABA-ergic synapse; Schaffer collateral - CA1 synapse; and glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Orthologous to human NPTN (neuroplastin). [provided by Alliance of Genome Resources, Apr 2022]

Nptn Products (4)

mRNA Protein Name
NM_001413347.1 NP_001400276.1 neuroplastin isoform 1 precursor
NM_001413348.1 NP_001400277.1 neuroplastin isoform 3 precursor
NM_001413349.1 NP_001400278.1 neuroplastin isoform 4 precursor
NM_019380.3 NP_062253.1 neuroplastin isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cell adhesion molecule binding IDA
IDA: Inferred from direct assay
10759566 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
22389504 RGD
enables type 1 fibroblast growth factor receptor binding IDA
IDA: Inferred from direct assay
19952283 RGD
Biological Process GO Annotation Evidence References Source
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
10759566 RGD
involved in long-term synaptic potentiation IDA
IDA: Inferred from direct assay
16925595 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
19952283 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
19952283 RGD
involved in positive regulation of fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
19952283 RGD
involved in positive regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
10759566 RGD
involved in positive regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
10759566 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
19952283 RGD
involved in positive regulation of protein localization IMP
IMP: Inferred from mutant phenotype
22389504 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
16925595 RGD
involved in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission EXP
EXP: Inferred from Experiment
10759566 RGD
involved in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IDA
IDA: Inferred from direct assay
10759566 RGD
involved in visual learning IDA
IDA: Inferred from direct assay
21480899 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
22389504 RGD
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
10759566 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
10759566 RGD
located in cell surface IDA
IDA: Inferred from direct assay
10759566 RGD
located in dendrite IDA
IDA: Inferred from direct assay
22389504 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23622064 RGD
located in inhibitory synapse IDA
IDA: Inferred from direct assay
22389504 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
3224275 RGD
is active in presynaptic active zone membrane EXP
EXP: Inferred from Experiment
23622064 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
23622064 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
11431460 RGD
is active in synaptic membrane IDA
IDA: Inferred from direct assay
22389504 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
1573391 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroplastin

  • glycoprotein 55

  • glycoprotein 55/65

  • glycoprotein 65

  • gp55/65

  • stromal cell derived factor receptor 1

  • stromal cell-derived receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09504 NPTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19925 Nptn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26427 Nptn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nptn NCBI NCBI:27020