MMP26 - matrix metallopeptidase 26 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56547

About MMP26

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,704,784-4,992,429 (from NCBI)

This gene has 3 transcripts (splice variants), 513 orthologues and 23 paralogues. Restricted expression toward endometrium (RPKM 7.9).

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade Collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]

MMP26 Products (2)

mRNA Protein Name
NM_001384608.1 NP_001371537.1 matrix metalloproteinase-26 isoform 2
NM_021801.5 NP_068573.2 matrix metalloproteinase-26 isoform 1 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
23569462 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP26 Protein Structure

Peptidase_M10

Peptidase_M10: Matrixin (98 - 253)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-26

  • MMP-26

Recombinant MMP26 Proteins

Cat. No. Product Name Accession Purity
HY-P76498 MMP-26 Protein, Human Q9NRE1 (T90-P261) ≥ 90%, as determined by reducing SDS-PAGE.

MMP26 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83495 MMP26 Antibody (YA3240) WB Human, Hamster, Rat
HY-P83495A MMP26 Antibody (YA3240)(PBS only) WB Human, Hamster, Rat

Related Diseases

Diseases Alias
Endometrial Hyperplasia
Pyoderma Gangrenosum

  • Phagedenic Pyoderma

  • Phagedena Geometric
Pyoderma
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2682 MMP-8/MMP-26 Fluorogenic substrate / Unkown
HY-P3098 Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 / Unkown
HY-RS08545 MMP26 Human Pre-designed siRNA Set A Pre-designed Set / Unkown