RCN1 - reticulocalbin 1 Gene

Also Known as RCN; RCAL; PIG20; HEL-S-84

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5954

About RCN1

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:32,091,074-32,105,722 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 4 paralogues. Ubiquitous expression in placenta (RPKM 69.9), urinary bladder (RPKM 61.7) and 24 other tissues.

Summary

Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity CA(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate Cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]

RCN1 Products (1)

mRNA Protein Name
NM_002901.4 NP_002892.1 reticulocalbin-1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCN1 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (84 - 143)

EF-hand_7

EF-hand_7: EF-hand domain pair (172 - 229)

EF-hand_6

EF-hand_6: EF-hand domain (249 - 273)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
Protein Preferred Names Protein Names

reticulocalbin-1

  • epididymis secretory protein Li 84

RCN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RCN1 Q15293 ATPAF2 Homo sapiens Q8N5M1
Validated Y2H
32296183
Intra
RCN1 Q15293 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra
RCN1 Q15293 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
RCN1 Q15293 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
Intra
RCN1 Q15293 DCAF11 Homo sapiens Q8TEB1
Validated Y2H
32296183
Intra
RCN1 Q15293 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
RCN1 Q15293 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
RCN1 Q15293 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
RCN1 Q15293 GTPBP3 Homo sapiens Q969Y2
Validated Y2H
32296183
Intra
RCN1 Q15293 EFHC1 Homo sapiens Q5JVL4
Validated Y2H
32296183
Intra
RCN1 Q15293 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
RCN1 Q15293 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
RCN1 Q15293 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RCN1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71820 RCN1 Protein, Human (P.pastoris, His) Q15293-1 (31P-L331) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

  • Wagr Syndrome

  • 11p Partial Monosomy Syndrome

  • Chromosome 11p13 Deletion Syndrome

  • Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome

  • 11p Deletion Syndrome

  • Chromosome 11p Deletion Syndrome

  • Wagr Complex

  • Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome

  • Deletion 11p13

  • WAGR

  • Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome

  • Chromosome 11p Deletion

  • 11p Deletion

  • 11p Monosomy

  • Deletion 11p

  • Monosomy 11p

  • Partial Monosomy 11p

  • Agr Triad

  • Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

  • Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

  • Wagr Contiguous Gene Syndrome

  • Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

  • Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome

  • Del(11)(P13)

  • Monosomy 11p13

  • Chromosome 11, Deletion 11p
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Aniridia 1

  • Aniridia

  • Congenital Aniridia

  • AN1

  • An

  • Cataract With Late-Onset Corneal Dystrophy

  • Aplasia Of Iris

  • Absent Iris

  • Irideremia

  • Aniridia Ii, Formerly

  • An2, Formerly

  • An2

  • Aniridia Type Ii

  • Aniridia, Type 1

  • An-1

  • Absence Of Iris

  • Agenesis Of Iris

  • Congenital Absence Of Iris

  • Hereditary Aniridia

  • Sporadic Aniridia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11779 RCAN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11788 RCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19156 Rcn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21728 Rcan1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25645 Rcn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RCN1 MGD MGI:104559
Rattus norvegicus RCN1 RGD RGD:1311292
Bos taurus RCN1 VGNC VGNC:33831
Canis familiaris RCN1 VGNC VGNC:52039
Macaca mulatta RCN1 VGNC VGNC:101389
Felis catus RCN1 VGNC VGNC:81953
Others RCN1 NCBI