S100A7 - S100 calcium binding protein A7 Gene

Also Known as PSOR1; S100A7c

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6278

About S100A7

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,457,744-153,460,651 (from NCBI)

This gene has 2 transcripts (splice variants), 271 orthologues, 21 paralogues and is associated with 35 phenotypes. Restricted expression toward skin (RPKM 64.2).

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the Other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]

S100A7 Products (1)

mRNA	Protein	Name
NM_002963.4	NP_002954.2	protein S100-A7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RAGE receptor binding	IPI IPI: Inferred from physical interaction	18606705	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	8077703	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12421467	GOA
enables zinc ion sequestering activity	IDA IDA: Inferred from direct assay	15568027	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: Inferred from mutant phenotype	15568027	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18606705	GOA
involved in positive regulation of T cell chemotaxis	IDA IDA: Inferred from direct assay	18606705	GOA
involved in positive regulation of granulocyte chemotaxis	IDA IDA: Inferred from direct assay	18606705	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	18606705	GOA
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17625598	GOA
involved in response to reactive oxygen species	IDA IDA: Inferred from direct assay	16082188	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10595935	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12839573	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12839573	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	11782356	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	21805676	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10595935	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A7 Protein Structure

S_100

0
101 a.a.

Protein Preferred Names	Protein Names
protein S100-A7	psoriasin 1

S100A7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	S100A7	P31151	S100A7L2	Homo sapiens	Q5SY68	Validated Y2H	32296183
Intra	S100A7	P31151	S100A7L2	Homo sapiens	Q5SY68	Y2H Array	32296183
Intra	S100A7	P31151	S100A7L2	Homo sapiens	Q5SY68	Y2H Prey Pooling	32296183
Intra	S100A7	P31151	S100A7L2	Homo sapiens	Q5SY68	Complementation	32296183
Intra	S100A7	P31151	CLVS2	Homo sapiens	Q5SYC1	Y2H Prey Pooling	32296183
Intra	S100A7	P31151	CLVS2	Homo sapiens	Q5SYC1	Validated Y2H	32296183
Intra	S100A7	P31151	CLVS2	Homo sapiens	Q5SYC1	Y2H Array	32296183
Intra	S100A7	P31151	RANBP9	Homo sapiens	Q96S59	Y2H	12421467
Intra	S100A7	P31151	RANBP9	Homo sapiens	Q96S59	Anti Bait CoIP	12421467

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71274	S100A7 Protein, Human	P31151 (M1-Q101)	≥ 95%, as determined by reducing SDS-PAGE.

S100A7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811084	S100-A7 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Bladder Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Bladder Epidermoid Carcinoma Of The Urinary Bladder Carcinoma Squamous Cell Bladder
Psoriasis
Renal Infectious Disease
Hidradenitis Suppurativa	Acne Inversa Suppurative Hidradenitis Acne Inversa, Familial Apocrinitis Hidradenitides, Suppurative Hidradenitis, Suppurative Suppurative Hidradenitides Inverse Acne
Hidradenitis	Hydradenitis
Porokeratosis	Disseminated Superficial Actinic Porokeratosis Dsap Porokeratosis Of Mibelli Porokeratosis, Disseminated Superficial Actinic Porokeratosis, Disseminated Superficial Actinic, 1
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Skin Carcinoma In Situ	Carcinoma In Situ Of Skin Cutaneous Carcinoma In Situ
Acne	Acne Vulgaris Acne Varioliformis Frontalis Acne
Pulmonary Systemic Sclerosis	Lung Disease With Systemic Sclerosis Lung Involvement In Systemic Sclerosis
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Breast Ductal Carcinoma	Ductal Breast Carcinoma Duct Carcinoma Carcinoma, Ductal Mammary Ductal Carcinoma Ductal Carcinoma
Tinea Pedis	Athlete'S Foot Dermatophytosis Of Foot Ringworm Of Foot Moccasin Foot
Autoimmune Disease Of Skin And Connective Tissue
Psoriasis 4	PSORS4 Psoriasis Susceptibility 4 Psoriasis 4, Susceptibility To
Dermatophytosis	Tinea Dermatophytosis, Unspecified Ringworm Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton Cutaneous Mycosis Dermal Mycosis Superficial Mycosis, Unspecified Fungus Infection Of Skin Skin Mycosis Dermatitis Fungoid Fungal Dermatitis Fungal Dermatosis Mycotic Infection Of Skin
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ductal Carcinoma In Situ	Noninfiltrating Intraductal Carcinoma
Breast Carcinoma In Situ	Carcinoma In Situ Of Breast Non-Infiltrating Carcinoma Of Breast Breast Cancer In Situ
Pre-Malignant Neoplasm
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12383	S100A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12384	S100A7A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	S100A7	MGD	MGI:2687194
Others	S100A7	NCBI