ECSCR - endothelial cell surface expressed chemotaxis and apoptosis regulator Gene

Also Known as ARIA; ECSM2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 641700

About ECSCR

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,448,560-139,462,743 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele and 92 orthologues. Broad expression in placenta (RPKM 24.9), lung (RPKM 23.6) and 22 other tissues.

Summary

The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ECSCR Products (2)

mRNA Protein Name
NM_001077693.4 NP_001071161.1 endothelial cell-specific chemotaxis regulator isoform 1 precursor
NM_001293739.2 NP_001280668.1 endothelial cell-specific chemotaxis regulator isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19416853 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
19416853 GOA
acts upstream of or within positive regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19416853 GOA
acts upstream of or within positive regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
19416853 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
19416853 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19416853 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelial cell-specific chemotaxis regulator

  • apoptosis regulator through modulating IAP expression

ECSCR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ECSCR Q19T08 PTEN Homo sapiens P60484-1
BiFC
21593423
Intra
ECSCR Q19T08 PTEN Homo sapiens P60484-1
Anti Tag CoIP
21593423
Intra
ECSCR Q19T08 PSMA7 Homo sapiens O14818
Anti Tag CoIP
19416853
Intra
ECSCR Q19T08 PSMA7 Homo sapiens O14818
Y2H
19416853
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ECSCR Proteins

Cat. No. Product Name Accession Purity
HY-P77919 ECSCR Protein, Human (HEK293, Fc) Q19T08 (Q25-A124) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04147 ECSCR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18811 Ecscr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25301 Ecscr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ECSCR RGD RGD:1594804
Mus musculus ECSCR MGD MGI:1915795